Tbio HK3 Hexokinase-3

Protein Summary

Description

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• P52790
• Q8N1E7

Gene Name

• HK3

Ensembl ID

• ENST00000292432
• ENSP00000292432
• ENSG00000160883

Symbol

• HXK3
• HKIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
tissue sample	0.66
protein domain	0.58
pathway	0.56
gene perturbation	0.55

Protein Classes

DTO Classes

Protein / Kinase / Unclassified Protein / Hexokinase-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.03   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 421   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.03   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0