You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
HK1
Hexokinase-1

Protein Summary
Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298649
  • ENSP00000298649
  • ENSG00000156515
  • ENST00000359426
  • ENSP00000352398
  • ENST00000360289
  • ENSP00000353433
  • ENST00000436817
  • ENSP00000415949
  • ENST00000448642
  • ENSP00000402103
  • ENST00000643399
  • ENSP00000494664

Symbol
  • HK
  • HKD
  • HKI
  • HXK1
  • RP79
  • HMSNR
  • HK1-ta
  • HK1-tb
  • HK1-tc
  • hexokinase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
molecular function
0.95
gene perturbation
0.85
PubMedID
0.83
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.94   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 776   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.94   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 776   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0