HJURP
Holliday junction recognition protein
Protein Summary
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
- ENST00000411486
- ENSP00000414109
- ENSG00000123485
- ENST00000432087
- ENSP00000407208
- ENST00000441687
- ENSP00000401944
- FAKTS
- FLEG1
- URLC9
- FAKTS
- URLC9
- hFLEG1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
kinase perturbation | 0.81 | ||
histone modification site profile | 0.79 | ||
cellular component | 0.71 | ||
tissue sample | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.36 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 126 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.36 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 126 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (223)
CENPA
Novelty: 0.00154245
p_int: 0.999939761
p_ni: 0.000060239
Score: 0.999
Data Source: BioPlex,STRINGDB
DUS1L
Family: Enzyme
Novelty: 0.15534492
p_int: 0.993164779
p_ni: 0.002804583
p_wrong: 0.004030639
Score: 0.485
Data Source: BioPlex,STRINGDB
HIST1H4A
Novelty: 0.00279614
p_int: 0.992144435
p_ni: 0.007855565
Score: 0.905
Data Source: BioPlex,STRINGDB
NPM1
Novelty: 0.0005485
p_int: 0.91790325
p_ni: 0.08209675
Score: 0.943
Data Source: BioPlex,STRINGDB
MIS18A
Novelty: 0.08143008
p_int: 0.872081388
p_ni: 0.003070214
p_wrong: 0.124848398
Score: 0.959
Data Source: BioPlex,STRINGDB
LRRC46
Novelty: 1.159245
p_int: 0.769115098
p_ni: 0.230816926
p_wrong: 0.000067975
Score: 0.163
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Chromosome Maintenance | ||||
Reactome | Deposition of new CENPA-containing nucleosomes at the centromere | ||||
Reactome | Nucleosome assembly | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Chromosome Maintenance | ||||
Deposition of new CENPA-containing nucleosomes at the centromere | ||||
Nucleosome assembly | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (3)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
bilirubin measurement | 16 | 55 | 108 | 100 | |||||
blood metabolite measurement | 1 | 2 | 8 | 95.6 | |||||
serum metabolite measurement | 2 | 2 | 10 | 92.6 | |||||
6 | 4 | 0 | 1.1 | 91 | |||||
metabolite measurement | 1 | 1 | 1 | 86.4 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
bilirubin measurement | 108 | 100 | |||||
blood metabolite measurement | 8 | 95.6 | |||||
serum metabolite measurement | 10 | 92.6 | |||||
0 | 1.1 | 91 | |||||
metabolite measurement | 1 | 86.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Holliday junction recognition protein | VGNC:1960 | 460034 | |||||
Macaque | Holliday junction recognition protein | 718180 | ||||||
Mouse | MGI:2685821 | 381280 | ||||||
Rat | RGD:1305846 | 316602 | ||||||
Dog | Holliday junction recognition protein | VGNC:41697 | 100684935 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Holliday junction recognition protein | |||||
Macaque | Holliday junction recognition protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | Holliday junction recognition protein | |||||
Publication Statistics
PubMed Score 54.36
PubMed score by year
PubTator Score 30.57
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
|---|