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Tbio
HIVEP2
Transcription factor HIVEP2

Protein Summary
Description
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000012134
  • ENSP00000012134
  • ENSG00000010818
  • ENST00000367603
  • ENSP00000356575
  • ENST00000367604
  • ENSP00000356576

Symbol
  • SHN2
  • ZAS2
  • MBP-2
  • MIBP1
  • MRD43
  • ZNF40B
  • HIV-EP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
PubMedID
0.89
virus perturbation
0.88
disease perturbation
0.79
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999999997
p_wrong:  3e-9
Score:  0.566
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999597
p_ni:  4.03e-7
Data Source:  BioPlex
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.999952299
p_ni:  0.000041688
p_wrong:  0.000006013
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.999660511
p_ni:  0.000002728
p_wrong:  0.00033676
Score:  0.692
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
Score:  0.928
Data Source:  STRINGDB
CLIC4
Tbio
Family:  IC
Novelty:  0.01088335
Score:  0.715
Data Source:  STRINGDB
FUCA2
Tchem
Family:  Enzyme
Novelty:  0.02259158
Score:  0.683
Data Source:  STRINGDB
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
Score:  0.655
Data Source:  STRINGDB
ITGB1BP1
Tbio
Novelty:  0.03944856
Score:  0.654
Data Source:  STRINGDB
SSTR2
Tclin
Family:  GPCR
Novelty:  0.00200092
Score:  0.65
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
91.2
body mass index
2
2
2
74
eosinophil count
2
2
2
69.6
red blood cell distribution width
1
1
1
68.8
3
3
2
1
68.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
91.2
body mass index
2
74
eosinophil count
2
69.6
red blood cell distribution width
1
68.8
2
1
68.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
human immunodeficiency virus type I enhancer binding protein 2
463035
Macaque
human immunodeficiency virus type I enhancer binding protein 2
701340
Mouse
MGI:1338076
15273
Rat
RGD:61988
29721
Dog
human immunodeficiency virus type I enhancer binding protein 2
484014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
human immunodeficiency virus type I enhancer binding protein 2
Macaque
human immunodeficiency virus type I enhancer binding protein 2
Mouse
Rat
Dog
human immunodeficiency virus type I enhancer binding protein 2
Publication Statistics
PubMed Score 42.76
PubMed score by year
PubTator Score 21.58
PubTator score by year
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Related Publications
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PMID
Year
Title