HIST3H2A
Histone H2A type 3
Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A f ...more
- ENST00000366695
- ENSP00000355656
- ENSG00000181218
- ENST00000645741
- ENSP00000493926
- ENSG00000284841
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
cellular component | 0.88 | ||
cell type or tissue | 0.82 | ||
transcription factor binding site profile | 0.79 | ||
histone modification site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.05 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 63 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.05 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 63 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (181)
Nearest Tclin Targets
Pathways (14)
Reactome (11)
KEGG (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Deubiquitination | ||||
Reactome | HATs acetylate histones | ||||
Reactome | HDACs deacetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Deubiquitination | ||||
HATs acetylate histones | ||||
HDACs deacetylate histones | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 5.5 | 60.4 | |||||
electrocardiography | 1 | 1 | 1 | 40.1 | |||||
creatinine measurement | 1 | 1 | 1 | 38.8 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 1 | 1 | 0 | 15744.7 | 13.1 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 5.5 | 60.4 | |||||
electrocardiography | 1 | 40.1 | |||||
creatinine measurement | 1 | 38.8 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 0 | 15744.7 | 13.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2448458 | 319162 | ||||||
Horse | histone H2A type 3 | 100061017 | ||||||
Cow | histone cluster 3, H2a | 538911 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Horse | histone H2A type 3 | |||||
Cow | histone cluster 3, H2a | |||||
Publication Statistics
PubMed Score 3.05
PubMed score by year
Related Publications
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Text |
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