Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family a ...more
- ENST00000369167
- ENSP00000358164
- ENSG00000203814
- ENST00000545683
- ENSP00000445831
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.83 | ||
microRNA | 0.74 | ||
histone modification site profile | 0.7 | ||
cell line | 0.62 | ||
interacting protein | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.49 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 175 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.49 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 175 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (110)
MECP2
Family: TF
Novelty: 0.00051767
p_int: 0.999999358
p_ni: 4.9e-8
p_wrong: 5.93e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
RPL10A
Novelty: 0.01747453
p_int: 0.999999189
p_ni: 3.6e-8
p_wrong: 7.75e-7
Score: 0.832
Data Source: BioPlex,STRINGDB
RBM34
Novelty: 0.58131282
p_int: 0.999998581
p_ni: 7e-9
p_wrong: 0.000001412
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (8)
KEGG (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Deubiquitination | ||||
Reactome | HATs acetylate histones | ||||
Reactome | HDACs deacetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Deubiquitination | ||||
HATs acetylate histones | ||||
HDACs deacetylate histones | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (5)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 3 | 2 | 3 | 71.8 | |||||
high density lipoprotein cholesterol measurement | 2 | 2 | 2 | 57.2 | |||||
triglyceride measurement | 3 | 2 | 3 | 54.1 | |||||
heel bone mineral density | 1 | 1 | 1 | 42.3 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 38.1 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 3 | 71.8 | |||||
high density lipoprotein cholesterol measurement | 2 | 57.2 | |||||
triglyceride measurement | 3 | 54.1 | |||||
heel bone mineral density | 1 | 42.3 | |||||
apolipoprotein A 1 measurement | 2 | 38.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2448413 | 319189 | ||||||
Platypus | histone H2B type 2-E-like | 100093284 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Platypus | histone H2B type 2-E-like | |||||
Publication Statistics
PubMed Score 1.49
PubMed score by year
PubTator Score 0.36
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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