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Tbio
HIST2H2AC
Histone H2A type 2-C

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331380
  • ENSP00000332194
  • ENSG00000184260

Symbol
  • H2AFQ
  • H2A
  • H2A/q
  • H2AFQ
  • H2A-GL101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
histone modification site profile
0.9
cellular component
0.84
transcription factor binding site profile
0.76
interacting protein
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1362.89   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1362.89   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (570)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.999998913
p_ni:  2.1e-8
p_wrong:  0.000001066
Score:  0.152
Data Source:  BioPlex,STRINGDB
FOXP2
Tbio
Family:  TF
Novelty:  0.00190504
p_int:  0.999989263
p_ni:  0.000007689
p_wrong:  0.000003048
Score:  0.197
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.999986397
p_ni:  0.000013602
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.999957972
p_ni:  0.000033482
p_wrong:  0.000008546
Data Source:  BioPlex
MAP3K13
Tchem
Family:  Kinase
Novelty:  0.00461563
p_int:  0.999575675
p_ni:  0.000424325
Score:  0.327
Data Source:  BioPlex,STRINGDB
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
p_int:  0.999562465
p_ni:  0.000437535
Score:  0.304
Data Source:  BioPlex,STRINGDB
LINGO1
Tbio
Novelty:  0.00778085
p_int:  0.999427342
p_ni:  0.000559681
p_wrong:  0.000012977
Score:  0.158
Data Source:  BioPlex,STRINGDB
VSX1
Tbio
Family:  TF
Novelty:  0.01213324
p_int:  0.998583016
p_ni:  0.001350614
p_wrong:  0.000066369
Score:  0.28
Data Source:  BioPlex,STRINGDB
ALDH3A1
Tchem
Family:  Enzyme
Novelty:  0.00592398
p_int:  0.946025016
p_ni:  0.005253233
p_wrong:  0.04872175
Score:  0.194
Data Source:  BioPlex,STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (85)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
Items per page:
1 – 5 of 80
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
10
97.7
body height
6
3
5
5.1
92.7
BMI-adjusted waist circumference
7
3
15
88.8
sex hormone-binding globulin measurement
5
3
5
87.9
body fat distribution
2
1
6
87.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
97.7
body height
5
5.1
92.7
BMI-adjusted waist circumference
15
88.8
sex hormone-binding globulin measurement
5
87.9
body fat distribution
6
87.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 1362.89
PubMed score by year
PubTator Score 1.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title