Tbio HIST2H2AB Histone H2A type 2-B

Protein Summary

Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• Q8IUE6

Gene Name

• HIST2H2AB

Ensembl ID

• ENST00000331128
• ENSP00000332790
• ENSG00000184270

Symbol

• H2AB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.79
cell type or tissue	0.73
transcription factor binding site profile	0.68
interacting protein	0.62
tissue sample	0.58

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H2a Type 2-b

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H2a Type 2-b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.87   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 52   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.87   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (207)

Explore Interacting Targets

1 – 10 of 207

• See Interactions on String-DB

H2AFX

Tbio

Novelty:  0.00048694

p_int:  0.999973753

p_ni:  0.000026247

Data Source:  BioPlex

HIST1H2BA

Tbio

Novelty:  0.02431803

p_int:  0.995214042

p_ni:  0.004785953

p_wrong:  4e-9

Score:  0.97

Data Source:  BioPlex,STRINGDB

FAM24B

Tdark

Novelty:  1.04675689

p_int:  0.991974892

p_ni:  0.008013579

p_wrong:  0.000011529

Data Source:  BioPlex

XPC

Tbio

Novelty:  0.00775175

p_int:  0.989673869

p_ni:  0.010303629

p_wrong:  0.000022501

Score:  0.653

Data Source:  BioPlex,STRINGDB

H1FNT

Tdark

Novelty:  0.05593238

p_int:  0.983593466

p_ni:  0.014979273

p_wrong:  0.001427261

Data Source:  BioPlex

H2AFY2

Tbio

Novelty:  0.09948698

p_int:  0.977237917

p_ni:  0.02276208

p_wrong:  3e-9

Score:  0.603

Data Source:  BioPlex,STRINGDB

ZNF491

Tdark

Family:  TF

Novelty:  4.75862069

p_int:  0.972788213

p_ni:  0.027195226

p_wrong:  0.000016562

Score:  0.17

Data Source:  BioPlex,STRINGDB

HIST1H3A

Tbio

Novelty:  0.00991842

p_int:  0.937291331

p_ni:  0.062678664

p_wrong:  0.000030006

Score:  0.809

Data Source:  BioPlex,STRINGDB

SSRP1

Tbio

Family:  TF

Novelty:  0.0143993

p_int:  0.935107288

p_ni:  0.064892531

p_wrong:  1.8e-7

Score:  0.645

Data Source:  BioPlex,STRINGDB

RPS13

Tbio

Novelty:  0.0019983

p_int:  0.924046605

p_ni:  0.073160226

p_wrong:  0.002793169

Score:  0.194

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (11)

KEGG (3)

Chromatin modifying enzymes (R-HSA-3247509)

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5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	Deubiquitination	278 targets	R-HSA-5688426
Reactome	HATs acetylate histones	107 targets	R-HSA-3214847
Reactome	HDACs deacetylate histones	60 targets	R-HSA-3214815

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
Deubiquitination	278 targets	R-HSA-5688426
HATs acetylate histones	107 targets	R-HSA-3214847
HDACs deacetylate histones	60 targets	R-HSA-3214815

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (2)

Components (4)

Processes (1)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (27)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	7	3	6	5.1	97.3
BMI-adjusted hip circumference	EFO_0008039	4	6	11		96.2
BMI-adjusted waist circumference	EFO_0007789	7	3	15		92.7
body fat distribution	EFO_0004341	2	1	6		91.7
sex hormone-binding globulin measurement	EFO_0004696	5	3	5		87.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	6	5.1	97.3
BMI-adjusted hip circumference	EFO_0008039	11		96.2
BMI-adjusted waist circumference	EFO_0007789	15		92.7
body fat distribution	EFO_0004341	6		91.7
sex hormone-binding globulin measurement	EFO_0004696	5		87.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Chromosome
Citrullination
Complete proteome
DNA-binding
Hydroxylation
Isopeptide bond
Methylation
Nucleosome core
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
adolescent idiopathic scoliosis
anthropometric measurement
apolipoprotein A 1 measurement
appendicular lean mass
balding measurement
BMI-adjusted hip circumference
BMI-adjusted waist circumference
body fat distribution
body fat percentage
body height

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	histone cluster 2, H2ab		705170
Mouse	histone cluster 2, H2ab	MGI:2448314	621893
Rat	histone cluster 2 H2A family member b	RGD:1584064	690102
Horse	histone H2A type 2-B		106783189
Cow	histone cluster 2, H2ab		614974

Species	Name	OMA	EggNOG	Inparanoid
Macaque	histone cluster 2, H2ab
Mouse	histone cluster 2, H2ab
Rat	histone cluster 2 H2A family member b
Horse	histone H2A type 2-B
Cow	histone cluster 2, H2ab

Publication Statistics

PubMed Score 22.87

PubMed score by year

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PubTator Score 4.80

PubTator score by year

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Related Publications

GeneRif Annotations (2)

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10

0 of 0

PMID	Text