Tchem HIST1H4A Histone H4

Protein Summary

Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P62805
• A2VCL0
• P02304
• P02305
• Q6DRA9
• Q6FGB8
• Q6NWP7

Gene Name

• HIST1H4A

Ensembl ID

• ENST00000244537
• ENSP00000244537
• ENSG00000274618
• ENST00000355057
• ENSP00000347168
• ENSG00000197238
• ENST00000358064
• ENSP00000350767
• ENSG00000197837
• ENST00000377727
• ENSP00000366956
• ENSG00000158406
• ENST00000377745
• ENSP00000366974
• ENSG00000278705
• ENST00000377803
• ENSP00000367034
• ENSG00000197061
• ENST00000539745
• ENSP00000443017
• ENST00000578186
• ENSP00000462667
• ENSG00000270882
• ENST00000579512
• ENSP00000462355
• ENSG00000270276
• ENST00000611927
• ENSP00000479794
• ENSG00000273542
• ENST00000612061
• ENSP00000482412
• ENST00000613412
• ENSP00000481343
• ENST00000614247
• ENSP00000479461
• ENSG00000277157
• ENST00000614272
• ENSP00000478519
• ENST00000615164
• ENSP00000484789
• ENSG00000276966
• ENST00000615353
• ENSP00000481486
• ENSG00000276180
• ENST00000617569
• ENSP00000479106
• ENSG00000278637
• ENST00000618193
• ENSP00000478786
• ENST00000618305
• ENSP00000480960
• ENSG00000275126
• ENST00000621520
• ENSP00000481507
• ENST00000634560
• ENSP00000489319
• ENST00000634956
• ENSP00000489567
• ENST00000635491
• ENSP00000489236

Symbol

• H4/A
• H4FA
• H4/p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.97
disease	0.87
cell line	0.69
tissue sample	0.69
transcription factor binding site profile	0.66

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H4

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 514.39   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 1748   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 514.39   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 1748   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (61)

Explore Active Ligands

1 – 10 of 61

US9266891, III-28

HIST1H4ATchem

pIC50 : 9

US9266891, III-26

HIST1H4ATchem

pIC50 : 8.3

US9266891, I-5

HIST1H4ATchem

pIC50 : 8.1

US9266891, III-13

HIST1H4ATchem

pIC50 : 8.05

US9266891, II-2

HIST1H4ATchem

pIC50 : 7.82

US9266891, III-39

HIST1H4ATchem

pIC50 : 6.9

US9266891, III-15

HIST1H4ATchem

pIC50 : 8.52

US9266891, III-22

HIST1H4ATchem

pIC50 : 8.52

US9266891, III-23

HIST1H4ATchem

pIC50 : 8.52

US9266891, II-1

HIST1H4ATchem

pIC50 : 8.4

Protein-Protein Interactions (417)

Explore Interacting Targets

1 – 10 of 417

• See Interactions on String-DB

ATP1A2

Tclin

Family:  Transporter

Novelty:  0.00606202

p_int:  0.999999839

p_ni:  1.61e-7

Data Source:  BioPlex

HIST1H2BD

Tbio

Novelty:  0.05094332

p_int:  0.999999636

p_ni:  3.64e-7

Score:  0.627

Data Source:  BioPlex,STRINGDB

HIST1H2BO

Tdark

Novelty:  0.3427419

p_int:  0.999999174

p_ni:  8.25e-7

p_wrong:  1e-9

Score:  0.805

Data Source:  BioPlex,STRINGDB

CHAF1A

Tbio

Novelty:  0.02129179

p_int:  0.999998637

p_ni:  0.000001363

Score:  0.458

Data Source:  BioPlex,STRINGDB

ATP1A4

Tclin

Family:  Transporter

Novelty:  0.01011201

p_int:  0.999997915

p_ni:  0.00000205

p_wrong:  3.5e-8

Data Source:  BioPlex

ATRX

Tbio

Novelty:  0.00114798

p_int:  0.999997867

p_ni:  0.000002134

Score:  0.493

Data Source:  BioPlex,STRINGDB

DAXX

Tbio

Novelty:  0.00348585

p_int:  0.99999581

p_ni:  0.000004191

Score:  0.901

Data Source:  BioPlex,STRINGDB

NPAT

Tbio

Novelty:  0.01063979

p_int:  0.999995173

p_ni:  0.000004828

Score:  0.412

Data Source:  BioPlex,STRINGDB

H2AFY2

Tbio

Novelty:  0.09948698

p_int:  0.999983506

p_ni:  0.000010107

p_wrong:  0.000006387

Score:  0.787

Data Source:  BioPlex,STRINGDB

MYH8

Tbio

Novelty:  0.01020559

p_int:  0.999979525

p_ni:  0.000020224

p_wrong:  2.51e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (99)

Reactome (91)

KEGG (3)

PathwayCommons (3)

WikiPathways (2)

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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5

1 – 5 of 91

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Name	Explore in Pharos	Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Amyloid fiber formation	79 targets	R-HSA-977225
B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (4)

Components (10)

Processes (15)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (588)

Items per page:

5

1 – 5 of 588

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	ENSG00000278637	6	8	13		99.7
red blood cell distribution width	EFO_0005192	ENSG00000278705	6	8	13		99.7
red blood cell distribution width	EFO_0005192	ENSG00000197061	6	7	10		99.6
hemoglobin measurement	EFO_0004509	ENSG00000278637	5	6	7		99.4
hemoglobin measurement	EFO_0004509	ENSG00000197061	5	6	7		99.4

Items per page:

5

1 – 5 of 588

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	13		99.7
red blood cell distribution width	EFO_0005192	13		99.7
red blood cell distribution width	EFO_0005192	10		99.6
hemoglobin measurement	EFO_0004509	7		99.4
hemoglobin measurement	EFO_0004509	7		99.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Chromosomal rearrangement
Chromosome
Citrullination
Complete proteome
Direct protein sequencing
DNA-binding
Hydroxylation
Isopeptide bond

GWAS Trait Find Similar Targets

No Header	No Header
adolescent idiopathic scoliosis
advanced glycosylation end product-specific receptor ligand measurement
Agents acting on the renin-angiotensin system use measurement
alcohol drinking
allergic rhinitis
anthropometric measurement
anti-Epstein Barr virus antibody measurement
anti-merkel cell virus antibody measurement
Anti-varicella zoster virus IgG measurement
apolipoprotein A 1 measurement

IDG Resources

No IDG generated resources found

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	histone cluster 1, H4a	MGI:2448419	326619

Species	Name	OMA	EggNOG	Inparanoid
Mouse	histone cluster 1, H4a

Publication Statistics

PubMed Score 514.39

PubMed score by year

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PubTator Score 2.44

PubTator score by year

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Related Publications

Text Mined References (141)

GeneRif Annotations (47)

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10

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PMID	Year	Title