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Tchem
HIST1H4A
Histone H4

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 fa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244537
  • ENSP00000244537
  • ENSG00000274618
  • ENST00000355057
  • ENSP00000347168
  • ENSG00000197238
  • ENST00000358064
  • ENSP00000350767
  • ENSG00000197837
  • ENST00000377727
  • ENSP00000366956
  • ENSG00000158406
  • ENST00000377745
  • ENSP00000366974
  • ENSG00000278705
  • ENST00000377803
  • ENSP00000367034
  • ENSG00000197061
  • ENST00000539745
  • ENSP00000443017
  • ENST00000578186
  • ENSP00000462667
  • ENSG00000270882
  • ENST00000579512
  • ENSP00000462355
  • ENSG00000270276
  • ENST00000611927
  • ENSP00000479794
  • ENSG00000273542
  • ENST00000612061
  • ENSP00000482412
  • ENST00000613412
  • ENSP00000481343
  • ENST00000614247
  • ENSP00000479461
  • ENSG00000277157
  • ENST00000614272
  • ENSP00000478519
  • ENST00000615164
  • ENSP00000484789
  • ENSG00000276966
  • ENST00000615353
  • ENSP00000481486
  • ENSG00000276180
  • ENST00000617569
  • ENSP00000479106
  • ENSG00000278637
  • ENST00000618193
  • ENSP00000478786
  • ENST00000618305
  • ENSP00000480960
  • ENSG00000275126
  • ENST00000621520
  • ENSP00000481507
  • ENST00000634560
  • ENSP00000489319
  • ENST00000634956
  • ENSP00000489567
  • ENST00000635491
  • ENSP00000489236

Symbol
  • H4/A
  • H4FA
  • H4/p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.97
disease
0.87
cell line
0.69
tissue sample
0.69
transcription factor binding site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 603.07   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 1748   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 603.07   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 1748   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (417)
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
p_int:  0.999999839
p_ni:  1.61e-7
Data Source:  BioPlex
HIST1H2BD
Tbio
Novelty:  0.05094332
p_int:  0.999999636
p_ni:  3.64e-7
Score:  0.627
Data Source:  BioPlex,STRINGDB
HIST1H2BO
Tdark
Novelty:  0.3427419
p_int:  0.999999174
p_ni:  8.25e-7
p_wrong:  1e-9
Score:  0.805
Data Source:  BioPlex,STRINGDB
CHAF1A
Tbio
Novelty:  0.02129179
p_int:  0.999998637
p_ni:  0.000001363
Score:  0.458
Data Source:  BioPlex,STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
p_int:  0.999997915
p_ni:  0.00000205
p_wrong:  3.5e-8
Data Source:  BioPlex
ATRX
Tbio
Novelty:  0.00114798
p_int:  0.999997867
p_ni:  0.000002134
Score:  0.493
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.99999581
p_ni:  0.000004191
Score:  0.901
Data Source:  BioPlex,STRINGDB
NPAT
Tbio
Novelty:  0.01063979
p_int:  0.999995173
p_ni:  0.000004828
Score:  0.412
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.999983506
p_ni:  0.000010107
p_wrong:  0.000006387
Score:  0.787
Data Source:  BioPlex,STRINGDB
MYH8
Tbio
Novelty:  0.01020559
p_int:  0.999979525
p_ni:  0.000020224
p_wrong:  2.51e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (99)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
Items per page:
1 – 5 of 91
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (761)
Items per page:
1 – 5 of 761
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
11
7
11
5.6
99.5
body height
11
7
11
5.6
99.5
body height
11
7
11
5.6
99.5
hemoglobin measurement
7
7
9
99.3
hemoglobin measurement
7
7
9
99.3
Items per page:
1 – 5 of 761
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
11
5.6
99.5
body height
11
5.6
99.5
body height
11
5.6
99.5
hemoglobin measurement
9
99.3
hemoglobin measurement
9
99.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 603.07
PubMed score by year
PubTator Score 2.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title