Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 fa ...more
- ENST00000244537
- ENSP00000244537
- ENSG00000274618
- ENST00000355057
- ENSP00000347168
- ENSG00000197238
- ENST00000358064
- ENSP00000350767
- ENSG00000197837
- ENST00000377727
- ENSP00000366956
- ENSG00000158406
- ENST00000377745
- ENSP00000366974
- ENSG00000278705
- ENST00000377803
- ENSP00000367034
- ENSG00000197061
- ENST00000539745
- ENSP00000443017
- ENST00000578186
- ENSP00000462667
- ENSG00000270882
- ENST00000579512
- ENSP00000462355
- ENSG00000270276
- ENST00000611927
- ENSP00000479794
- ENSG00000273542
- ENST00000612061
- ENSP00000482412
- ENST00000613412
- ENSP00000481343
- ENST00000614247
- ENSP00000479461
- ENSG00000277157
- ENST00000614272
- ENSP00000478519
- ENST00000615164
- ENSP00000484789
- ENSG00000276966
- ENST00000615353
- ENSP00000481486
- ENSG00000276180
- ENST00000617569
- ENSP00000479106
- ENSG00000278637
- ENST00000618193
- ENSP00000478786
- ENST00000618305
- ENSP00000480960
- ENSG00000275126
- ENST00000621520
- ENSP00000481507
- ENST00000634560
- ENSP00000489319
- ENST00000634956
- ENSP00000489567
- ENST00000635491
- ENSP00000489236
- H4/A
- H4FA
- H4/p
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.97 | ||
disease | 0.87 | ||
cell line | 0.69 | ||
tissue sample | 0.69 | ||
transcription factor binding site profile | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 514.39 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 1748 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 514.39 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 1748 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 61
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (61)
Protein-Protein Interactions (417)
ATP1A2
Family: Transporter
Novelty: 0.00606202
p_int: 0.999999839
p_ni: 1.61e-7
Data Source: BioPlex
HIST1H2BD
Novelty: 0.05094332
p_int: 0.999999636
p_ni: 3.64e-7
Score: 0.627
Data Source: BioPlex,STRINGDB
HIST1H2BO
Novelty: 0.3427419
p_int: 0.999999174
p_ni: 8.25e-7
p_wrong: 1e-9
Score: 0.805
Data Source: BioPlex,STRINGDB
CHAF1A
Novelty: 0.02129179
p_int: 0.999998637
p_ni: 0.000001363
Score: 0.458
Data Source: BioPlex,STRINGDB
ATP1A4
Family: Transporter
Novelty: 0.01011201
p_int: 0.999997915
p_ni: 0.00000205
p_wrong: 3.5e-8
Data Source: BioPlex
ATRX
Novelty: 0.00114798
p_int: 0.999997867
p_ni: 0.000002134
Score: 0.493
Data Source: BioPlex,STRINGDB
DAXX
Novelty: 0.00348585
p_int: 0.99999581
p_ni: 0.000004191
Score: 0.901
Data Source: BioPlex,STRINGDB
NPAT
Novelty: 0.01063979
p_int: 0.999995173
p_ni: 0.000004828
Score: 0.412
Data Source: BioPlex,STRINGDB
H2AFY2
Novelty: 0.09948698
p_int: 0.999983506
p_ni: 0.000010107
p_wrong: 0.000006387
Score: 0.787
Data Source: BioPlex,STRINGDB
MYH8
Novelty: 0.01020559
p_int: 0.999979525
p_ni: 0.000020224
p_wrong: 2.51e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (99)
Reactome (91)
KEGG (3)
PathwayCommons (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Amyloid fiber formation | ||||
B-WICH complex positively regulates rRNA expression | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (4)
Components (10)
Processes (15)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (588)
Items per page:
1 – 5 of 588
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 6 | 8 | 13 | 99.7 | ||||||
red blood cell distribution width | 6 | 8 | 13 | 99.7 | ||||||
red blood cell distribution width | 6 | 7 | 10 | 99.6 | ||||||
hemoglobin measurement | 5 | 6 | 7 | 99.4 | ||||||
hemoglobin measurement | 5 | 6 | 7 | 99.4 | ||||||
Items per page:
1 – 5 of 588
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 13 | 99.7 | |||||
red blood cell distribution width | 13 | 99.7 | |||||
red blood cell distribution width | 10 | 99.6 | |||||
hemoglobin measurement | 7 | 99.4 | |||||
hemoglobin measurement | 7 | 99.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:2448419 | 326619 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Publication Statistics
PubMed Score 514.39
PubMed score by year
PubTator Score 2.44
PubTator score by year
Related Publications
Text Mined References (141)
GeneRif Annotations (47)
Items per page:
0 of 0
PMID | Year | Title |
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