Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the hi ...more
- ENST00000356476
- ENSP00000366999
- ENSG00000197409
- ENST00000359303
- ENSP00000352252
- ENSG00000197153
- ENST00000369163
- ENSP00000358160
- ENSG00000278828
- ENST00000612966
- ENSP00000484658
- ENSG00000278272
- ENST00000613854
- ENSP00000480826
- ENSG00000275714
- ENST00000614378
- ENSP00000484638
- ENSG00000273983
- ENST00000614911
- ENSP00000482271
- ENSG00000274750
- ENST00000616365
- ENSP00000483283
- ENSG00000275379
- ENST00000618052
- ENSP00000484095
- ENSG00000277775
- ENST00000621411
- ENSP00000484841
- ENSG00000274267
- ENST00000634733
- ENSP00000489282
- H3FA
- H3/A
- H3FA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.73 | ||
cellular component | 0.7 | ||
histone modification site profile | 0.7 | ||
gene perturbation | 0.68 | ||
transcription factor | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.11 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 1676 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.11 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 1676 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (224)
CHAF1A
Novelty: 0.02129179
p_int: 0.999999405
p_ni: 5.95e-7
Score: 0.458
Data Source: BioPlex,STRINGDB
MMS22L
Novelty: 0.22570578
p_int: 0.999594935
p_ni: 0.000405064
p_wrong: 2e-9
Score: 0.249
Data Source: BioPlex,STRINGDB
MTA3
Family: TF
Novelty: 0.02667635
p_int: 0.999585301
p_ni: 0.000414699
p_wrong: 1e-9
Data Source: BioPlex
FBLIM1
Novelty: 0.0332985
p_int: 0.99935685
p_ni: 0.00042158
p_wrong: 0.000221571
Data Source: BioPlex
NASP
Novelty: 0.00902599
p_int: 0.999299658
p_ni: 0.000700342
Score: 0.573
Data Source: BioPlex,STRINGDB
UHRF1
Family: Epigenetic
Novelty: 0.00482565
p_int: 0.998842584
p_ni: 0.001157416
Score: 0.862
Data Source: BioPlex,Reactome,STRINGDB
SUPT16H
Family: Enzyme
Novelty: 0.01026868
p_int: 0.998783508
p_ni: 0.001216493
Score: 0.787
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (73)
Reactome (67)
KEGG (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Amyloid fiber formation | ||||
B-WICH complex positively regulates rRNA expression | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (3)
Components (9)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (351)
Items per page:
1 – 5 of 351
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 6 | 8 | 13 | 99.7 | ||||||
hemoglobin measurement | 5 | 6 | 7 | 99.4 | ||||||
hematocrit | 6 | 6 | 10 | 99.3 | ||||||
mean corpuscular hemoglobin concentration | 10 | 5 | 15 | 99.1 | ||||||
mean corpuscular volume | 5 | 5 | 8 | 99 | ||||||
Items per page:
1 – 5 of 351
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 13 | 99.7 | |||||
hemoglobin measurement | 7 | 99.4 | |||||
hematocrit | 10 | 99.3 | |||||
mean corpuscular hemoglobin concentration | 15 | 99.1 | |||||
mean corpuscular volume | 8 | 99 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:2668828 | 360198 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Publication Statistics
PubMed Score 20.11
PubMed score by year
PubTator Score 18.49
PubTator score by year
Related Publications
Text Mined References (99)
GeneRif Annotations (38)
Items per page:
0 of 0
PMID | Year | Title |
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