Tbio HIST1H3A Histone H3.1

Protein Summary

Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P68431
• A0PJT7
• A5PLR1
• P02295
• P02296
• P16106
• Q6ISV8
• Q6NWP8
• Q6NWP9
• Q6NXU4
• Q71DJ3
• Q93081

Gene Name

• HIST1H3A

Ensembl ID

• ENST00000356476
• ENSP00000366999
• ENSG00000197409
• ENST00000359303
• ENSP00000352252
• ENSG00000197153
• ENST00000369163
• ENSP00000358160
• ENSG00000278828
• ENST00000612966
• ENSP00000484658
• ENSG00000278272
• ENST00000613854
• ENSP00000480826
• ENSG00000275714
• ENST00000614378
• ENSP00000484638
• ENSG00000273983
• ENST00000614911
• ENSP00000482271
• ENSG00000274750
• ENST00000616365
• ENSP00000483283
• ENSG00000275379
• ENST00000618052
• ENSP00000484095
• ENSG00000277775
• ENST00000621411
• ENSP00000484841
• ENSG00000274267
• ENST00000634733
• ENSP00000489282

Symbol

• H3FA
• H3/A
• H3FA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.73
cellular component	0.7
histone modification site profile	0.7
gene perturbation	0.68
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.11   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 1676   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.11   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 1676   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (224)

Explore Interacting Targets

1 – 10 of 224

• See Interactions on String-DB

UBR7

Tbio

Family:  Epigenetic

Novelty:  0.23270052

p_int:  0.999999972

p_ni:  2.8e-8

Data Source:  BioPlex

CHAF1A

Tbio

Novelty:  0.02129179

p_int:  0.999999405

p_ni:  5.95e-7

Score:  0.458

Data Source:  BioPlex,STRINGDB

TONSL

Tbio

Novelty:  0.07220129

p_int:  0.999989579

p_ni:  0.000010422

Data Source:  BioPlex

MMS22L

Tbio

Novelty:  0.22570578

p_int:  0.999594935

p_ni:  0.000405064

p_wrong:  2e-9

Score:  0.249

Data Source:  BioPlex,STRINGDB

MTA3

Tbio

Family:  TF

Novelty:  0.02667635

p_int:  0.999585301

p_ni:  0.000414699

p_wrong:  1e-9

Data Source:  BioPlex

FBLIM1

Tbio

Novelty:  0.0332985

p_int:  0.99935685

p_ni:  0.00042158

p_wrong:  0.000221571

Data Source:  BioPlex

NASP

Tbio

Novelty:  0.00902599

p_int:  0.999299658

p_ni:  0.000700342

Score:  0.573

Data Source:  BioPlex,STRINGDB

MTA1

Tbio

Family:  TF

Novelty:  0.00464618

p_int:  0.999036294

p_ni:  0.000963706

Data Source:  BioPlex

UHRF1

Tbio

Family:  Epigenetic

Novelty:  0.00482565

p_int:  0.998842584

p_ni:  0.001157416

Score:  0.862

Data Source:  BioPlex,Reactome,STRINGDB

SUPT16H

Tbio

Family:  Enzyme

Novelty:  0.01026868

p_int:  0.998783508

p_ni:  0.001216493

Score:  0.787

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (73)

Reactome (67)

KEGG (3)

WikiPathways (3)

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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5

1 – 5 of 67

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Name	Explore in Pharos	Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Amyloid fiber formation	79 targets	R-HSA-977225
B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (25)

Functions (3)

Components (9)

Processes (13)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
nucleosomal DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (351)

Items per page:

5

1 – 5 of 351

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	ENSG00000275714	6	8	13		99.7
hemoglobin measurement	EFO_0004509	ENSG00000275714	5	6	7		99.4
hematocrit	EFO_0004348	ENSG00000275714	6	6	10		99.3
mean corpuscular hemoglobin concentration	EFO_0004528	ENSG00000275714	10	5	15		99.1
mean corpuscular volume	EFO_0004526	ENSG00000275714	5	5	8		99

Items per page:

5

1 – 5 of 351

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	13		99.7
hemoglobin measurement	EFO_0004509	7		99.4
hematocrit	EFO_0004348	10		99.3
mean corpuscular hemoglobin concentration	EFO_0004528	15		99.1
mean corpuscular volume	EFO_0004526	8		99

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
ADP-ribosylation
Chromosome
Citrullination
Complete proteome
Direct protein sequencing
Disease mutation
DNA-binding
Hydroxylation

GWAS Trait Find Similar Targets

No Header	No Header
advanced glycosylation end product-specific receptor ligand measurement
Agents acting on the renin-angiotensin system use measurement
alcohol drinking
allergic rhinitis
anthropometric measurement
anti-Epstein Barr virus antibody measurement
anti-merkel cell virus antibody measurement
Anti-varicella zoster virus IgG measurement
anxiety measurement
apolipoprotein A 1 measurement

IDG Resources

No IDG generated resources found

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	histone cluster 1, H3a	MGI:2668828	360198

Species	Name	OMA	EggNOG	Inparanoid
Mouse	histone cluster 1, H3a

Publication Statistics

PubMed Score 20.11

PubMed score by year

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PubTator Score 18.49

PubTator score by year

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Related Publications

Text Mined References (99)

GeneRif Annotations (38)

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10

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PMID	Year	Title