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Tbio
HIST1H3A
Histone H3.1

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the hi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356476
  • ENSP00000366999
  • ENSG00000197409
  • ENST00000359303
  • ENSP00000352252
  • ENSG00000197153
  • ENST00000369163
  • ENSP00000358160
  • ENSG00000278828
  • ENST00000612966
  • ENSP00000484658
  • ENSG00000278272
  • ENST00000613854
  • ENSP00000480826
  • ENSG00000275714
  • ENST00000614378
  • ENSP00000484638
  • ENSG00000273983
  • ENST00000614911
  • ENSP00000482271
  • ENSG00000274750
  • ENST00000616365
  • ENSP00000483283
  • ENSG00000275379
  • ENST00000618052
  • ENSP00000484095
  • ENSG00000277775
  • ENST00000621411
  • ENSP00000484841
  • ENSG00000274267
  • ENST00000634733
  • ENSP00000489282

Symbol
  • H3FA
  • H3/A
  • H3FA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
cellular component
0.7
histone modification site profile
0.7
gene perturbation
0.68
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.11   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 1676   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.11   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 1676   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (224)
UBR7
Tbio
Family:  Epigenetic
Novelty:  0.23270052
p_int:  0.999999972
p_ni:  2.8e-8
Data Source:  BioPlex
CHAF1A
Tbio
Novelty:  0.02129179
p_int:  0.999999405
p_ni:  5.95e-7
Score:  0.458
Data Source:  BioPlex,STRINGDB
TONSL
Tbio
Novelty:  0.07220129
p_int:  0.999989579
p_ni:  0.000010422
Data Source:  BioPlex
MMS22L
Tbio
Novelty:  0.22570578
p_int:  0.999594935
p_ni:  0.000405064
p_wrong:  2e-9
Score:  0.249
Data Source:  BioPlex,STRINGDB
MTA3
Tbio
Family:  TF
Novelty:  0.02667635
p_int:  0.999585301
p_ni:  0.000414699
p_wrong:  1e-9
Data Source:  BioPlex
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.99935685
p_ni:  0.00042158
p_wrong:  0.000221571
Data Source:  BioPlex
NASP
Tbio
Novelty:  0.00902599
p_int:  0.999299658
p_ni:  0.000700342
Score:  0.573
Data Source:  BioPlex,STRINGDB
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  0.999036294
p_ni:  0.000963706
Data Source:  BioPlex
UHRF1
Tbio
Family:  Epigenetic
Novelty:  0.00482565
p_int:  0.998842584
p_ni:  0.001157416
Score:  0.862
Data Source:  BioPlex,Reactome,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.998783508
p_ni:  0.001216493
Score:  0.787
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (73)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
Items per page:
1 – 5 of 67
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (351)
Items per page:
1 – 5 of 351
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
8
13
99.7
hemoglobin measurement
5
6
7
99.4
hematocrit
6
6
10
99.3
mean corpuscular hemoglobin concentration
10
5
15
99.1
mean corpuscular volume
5
5
8
99
Items per page:
1 – 5 of 351
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
13
99.7
hemoglobin measurement
7
99.4
hematocrit
10
99.3
mean corpuscular hemoglobin concentration
15
99.1
mean corpuscular volume
8
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 20.11
PubMed score by year
PubTator Score 18.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title