You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HIST1H2BJ
Histone H2B type 1-J

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339812
  • ENSP00000342886
  • ENSG00000124635
  • ENST00000607124
  • ENSP00000476136

Symbol
  • H2BFR
  • H2BJ
  • H2B/r
  • H2BFR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
interacting protein
0.86
transcription factor binding site profile
0.85
histone modification site profile
0.76
small molecule perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.47   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.47   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (425)
FGA
Tbio
Novelty:  0.00107227
p_int:  0.999999306
p_ni:  6.41e-7
p_wrong:  5.3e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.999998979
p_ni:  0.000001021
Data Source:  BioPlex
FGG
Tbio
Novelty:  0.00404457
p_int:  0.999997063
p_ni:  0.000002937
Score:  0.188
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.995084568
p_ni:  0.004914087
p_wrong:  0.000001345
Score:  0.16
Data Source:  BioPlex,STRINGDB
USP48
Tbio
Family:  Enzyme
Novelty:  0.10103618
p_int:  0.988848628
p_ni:  0.010004284
p_wrong:  0.001147089
Score:  0.286
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.956745834
p_ni:  0.043254166
Data Source:  BioPlex
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.84992759
p_ni:  0.143712288
p_wrong:  0.006360122
Data Source:  BioPlex
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
p_int:  0.810480128
p_ni:  0.189519717
p_wrong:  1.55e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
Score:  0.997
Data Source:  STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (92)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 89
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
liver iron measurement
1
2
2
89.4
4
4
0
1.2
86.4
BMI-adjusted hip circumference
3
7
7
84.8
wellbeing measurement
2
2
2
80.6
intelligence
2
4
2
7
72
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
liver iron measurement
2
89.4
0
1.2
86.4
BMI-adjusted hip circumference
7
84.8
wellbeing measurement
2
80.6
intelligence
2
7
72
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
histone H2B type 1-J
488288
Horse
histone H2B type 1-J
100053472
S.cerevisiae
S000000098
852284
Species
Name
OMA
EggNOG
Inparanoid
Dog
histone H2B type 1-J
Horse
histone H2B type 1-J
S.cerevisiae
Publication Statistics
PubMed Score 4.47
PubMed score by year
PubTator Score 3.03
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title