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Tbio
HIST1H2BA
Histone H2B type 1-A

Protein Summary
Description
Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274764
  • ENSP00000274764
  • ENSG00000146047

Symbol
  • TSH2B
  • STBP
  • TH2B
  • H2BFU
  • TSH2B
  • hTSH2B
  • TSH2B.1
  • bA317E16.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
pathway
0.66
interacting protein
0.6
gene perturbation
0.53
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.04   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.04   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (545)
MIER3
Tdark
Family:  TF
Novelty:  0.42079723
p_int:  0.999999977
p_ni:  2.2e-8
p_wrong:  1e-9
Score:  0.689
Data Source:  BioPlex,STRINGDB
BAHD1
Tbio
Novelty:  0.1601376
p_int:  0.999999963
p_ni:  1.1e-8
p_wrong:  2.6e-8
Score:  0.671
Data Source:  BioPlex,STRINGDB
PHF14
Tbio
Family:  Epigenetic
Novelty:  0.13279118
p_int:  0.999999945
p_ni:  5.3e-8
p_wrong:  1e-9
Score:  0.601
Data Source:  BioPlex,STRINGDB
HIST1H2BL
Tdark
Novelty:  0.64500134
p_int:  0.99999991
p_ni:  5.1e-8
p_wrong:  3.9e-8
Score:  0.912
Data Source:  BioPlex,STRINGDB
MIER1
Tbio
Novelty:  0.00357772
p_int:  0.999999836
p_ni:  1.64e-7
Score:  0.47
Data Source:  BioPlex,STRINGDB
GON4L
Tbio
Novelty:  0.06166736
p_int:  0.999999825
p_ni:  1.75e-7
Data Source:  BioPlex
ZNHIT1
Tbio
Novelty:  0.00390514
p_int:  0.999999673
p_ni:  3.08e-7
p_wrong:  1.9e-8
Score:  0.638
Data Source:  BioPlex,STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
p_int:  0.999999637
p_ni:  3.63e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
TONSL
Tbio
Novelty:  0.07220129
p_int:  0.999999436
p_ni:  5.64e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
ACTR6
Tbio
Novelty:  0.11005766
p_int:  0.999999338
p_ni:  6.62e-7
Score:  0.542
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (93)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
Items per page:
1 – 5 of 89
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
8
5
10
6.2
99.7
uric acid measurement
5
5
6
99.4
urinary metabolite measurement
1
3
4
95.6
blood metabolite measurement
2
3
3
94.6
high density lipoprotein cholesterol measurement
9
3
9
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
10
6.2
99.7
uric acid measurement
6
99.4
urinary metabolite measurement
4
95.6
blood metabolite measurement
3
94.6
high density lipoprotein cholesterol measurement
9
92.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2448375
319177
Rat
RGD:3855
24829
Horse
histone H2B type 1-A
100052703
Cow
histone cluster 1, H2ba
618216
S.cerevisiae
S000000098
852284
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
histone H2B type 1-A
Cow
histone cluster 1, H2ba
S.cerevisiae
Publication Statistics
PubMed Score 98.04
PubMed score by year
PubTator Score 21.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title