Protein Summary
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. ...more
- ENST00000338379
- ENSP00000341214
- ENSG00000187475
- H1FT
- H1T
- H1t
- H1.6
- H1FT
- dJ221C16.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.66 | ||
cellular component | 0.65 | ||
cell line | 0.61 | ||
cell type or tissue | 0.59 | ||
tissue sample | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.54 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 46 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.54 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 46 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (151)
ZC3HAV1
Novelty: 0.01357759
p_int: 0.999998283
p_ni: 0.000001717
Score: 0.23
Data Source: BioPlex,STRINGDB
H2AFX
Novelty: 0.00048694
p_int: 0.999997748
p_ni: 0.000002252
Score: 0.557
Data Source: BioPlex,STRINGDB
THAP3
Family: TF
Novelty: 0.52942342
p_int: 0.99999296
p_ni: 0.000007031
p_wrong: 9e-9
Data Source: BioPlex
HIST1H1E
Novelty: 0.01125284
p_int: 0.999991643
p_ni: 0.000008357
Score: 0.324
Data Source: BioPlex,STRINGDB
ZNF71
Family: TF
Novelty: 0.24703192
p_int: 0.999972904
p_ni: 0.000027092
p_wrong: 3e-9
Data Source: BioPlex
RPL23A
Novelty: 0.02951947
p_int: 0.999868158
p_ni: 0.00013184
p_wrong: 2e-9
Data Source: BioPlex
YBX2
Family: TF
Novelty: 0.01540247
p_int: 0.999861953
p_ni: 0.0001337
p_wrong: 0.000004347
Score: 0.602
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (3)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (80)
Items per page:
1 – 5 of 80
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 6 | 7 | 10 | 99.6 | |||||
hemoglobin measurement | 5 | 6 | 7 | 99.4 | |||||
hematocrit | 6 | 6 | 10 | 99.3 | |||||
mean corpuscular hemoglobin concentration | 10 | 5 | 15 | 99.1 | |||||
mean corpuscular volume | 5 | 5 | 8 | 99 | |||||
Items per page:
1 – 5 of 80
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 10 | 99.6 | |||||
hemoglobin measurement | 7 | 99.4 | |||||
hematocrit | 10 | 99.3 | |||||
mean corpuscular hemoglobin concentration | 15 | 99.1 | |||||
mean corpuscular volume | 8 | 99 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histone cluster 1 H1 family member t | VGNC:14371 | 471879 | |||||
Mouse | MGI:1888530 | 107970 | ||||||
Rat | RGD:2778 | 24438 | ||||||
Dog | histone cluster 1, H1t | 488266 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histone cluster 1 H1 family member t | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone cluster 1, H1t | |||||
Publication Statistics
PubMed Score 102.54
PubMed score by year
PubTator Score 43.21
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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