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Tdark
HIST1H1T
Histone H1t

Protein Summary
Description
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338379
  • ENSP00000341214
  • ENSG00000187475

Symbol
  • H1FT
  • H1T
  • H1t
  • H1.6
  • H1FT
  • dJ221C16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.66
cellular component
0.65
cell line
0.61
cell type or tissue
0.59
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.54   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.54   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.999998283
p_ni:  0.000001717
Score:  0.23
Data Source:  BioPlex,STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.999997945
p_ni:  0.000002055
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999997748
p_ni:  0.000002252
Score:  0.557
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.99999296
p_ni:  0.000007031
p_wrong:  9e-9
Data Source:  BioPlex
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.999991643
p_ni:  0.000008357
Score:  0.324
Data Source:  BioPlex,STRINGDB
ZNF71
Tbio
Family:  TF
Novelty:  0.24703192
p_int:  0.999972904
p_ni:  0.000027092
p_wrong:  3e-9
Data Source:  BioPlex
RPL23A
Tbio
Novelty:  0.02951947
p_int:  0.999868158
p_ni:  0.00013184
p_wrong:  2e-9
Data Source:  BioPlex
YBX2
Tbio
Family:  TF
Novelty:  0.01540247
p_int:  0.999861953
p_ni:  0.0001337
p_wrong:  0.000004347
Score:  0.602
Data Source:  BioPlex,STRINGDB
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.999855961
p_ni:  0.000144039
Data Source:  BioPlex
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.999766816
p_ni:  0.000233184
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (80)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
7
10
99.6
hemoglobin measurement
5
6
7
99.4
hematocrit
6
6
10
99.3
mean corpuscular hemoglobin concentration
10
5
15
99.1
mean corpuscular volume
5
5
8
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
99.6
hemoglobin measurement
7
99.4
hematocrit
10
99.3
mean corpuscular hemoglobin concentration
15
99.1
mean corpuscular volume
8
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member t
VGNC:14371
471879
Mouse
MGI:1888530
107970
Rat
RGD:2778
24438
Dog
histone cluster 1, H1t
488266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member t
Mouse
Rat
Dog
histone cluster 1, H1t
Publication Statistics
PubMed Score 102.54
PubMed score by year
PubTator Score 43.21
PubTator score by year
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Related Publications
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PMID
Year
Title