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Tbio
HIST1H1C
Histone H1.2

Protein Summary
Description
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343677
  • ENSP00000339566
  • ENSG00000187837

Symbol
  • H1F2
  • H1C
  • H1.2
  • H1F2
  • H1s-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor binding site profile
0.96
transcription factor perturbation
0.91
interacting protein
0.88
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.17   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.17   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.999999613
p_ni:  3.87e-7
Score:  0.258
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999999496
p_ni:  5.04e-7
Score:  0.541
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.9999991
p_ni:  8.99e-7
Data Source:  BioPlex
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.999994974
p_ni:  0.000005026
Score:  0.16
Data Source:  BioPlex,STRINGDB
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.999991774
p_ni:  0.000008226
Score:  0.587
Data Source:  BioPlex,STRINGDB
BHLHA15
Tbio
Family:  TF
Novelty:  0.02721846
p_int:  0.999981999
p_ni:  0.000018001
Data Source:  BioPlex
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.999917515
p_ni:  0.000082485
Data Source:  BioPlex
MRTO4
Tbio
Novelty:  0.06676322
p_int:  0.9998762
p_ni:  0.0001238
Score:  0.192
Data Source:  BioPlex,STRINGDB
IL17B
Tbio
Novelty:  0.02825795
p_int:  0.999839163
p_ni:  0.000160837
Data Source:  BioPlex
ZBTB48
Tbio
Family:  TF
Novelty:  0.07020518
p_int:  0.999709084
p_ni:  0.000290916
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cellular Senescence
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (65)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
7
10
99.6
hemoglobin measurement
5
6
7
99.4
hematocrit
6
6
10
99.3
mean corpuscular hemoglobin concentration
10
5
15
99.1
mean corpuscular volume
5
5
8
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
99.6
hemoglobin measurement
7
99.4
hematocrit
10
99.3
mean corpuscular hemoglobin concentration
15
99.1
mean corpuscular volume
8
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member c
VGNC:14360
471878
Mouse
MGI:1931526
50708
Dog
histone H1.2
488264
Horse
histone H1.2
100053307
Cow
histone cluster 1, H1c
513971
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member c
Mouse
Dog
histone H1.2
Horse
histone H1.2
Cow
histone cluster 1, H1c
Publication Statistics
PubMed Score 228.17
PubMed score by year
PubTator Score 80.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text