Protein Summary
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromi ...more
- ENST00000244573
- ENSP00000244573
- ENSG00000124610
- H1F1
- H1A
- H1.1
- H1F1
- HIST1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.99 | ||
tissue sample | 0.8 | ||
protein complex | 0.71 | ||
cellular component | 0.64 | ||
hub protein | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 811.32 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 308 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 811.32 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 308 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (200)
ZNF71
Family: TF
Novelty: 0.24703192
p_int: 0.999998739
p_ni: 0.000001261
Score: 0.151
Data Source: BioPlex,STRINGDB
ZCRB1
Novelty: 0.37592387
p_int: 0.999998539
p_ni: 0.000001461
Score: 0.56
Data Source: BioPlex,STRINGDB
STAU1
Novelty: 0.00565778
p_int: 0.999996331
p_ni: 0.000003669
Score: 0.223
Data Source: BioPlex,STRINGDB
H1FOO
Novelty: 0.02189067
p_int: 0.999984534
p_ni: 0.000015466
Score: 0.664
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptosis induced DNA fragmentation | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptosis induced DNA fragmentation | ||||
Apoptotic execution phase | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (4)
Components (6)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (62)
Items per page:
1 – 5 of 62
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 6 | 8 | 13 | 99.7 | |||||
hemoglobin measurement | 5 | 6 | 7 | 99.4 | |||||
hematocrit | 6 | 6 | 10 | 99.3 | |||||
mean corpuscular hemoglobin concentration | 10 | 5 | 15 | 99.1 | |||||
mean corpuscular volume | 5 | 5 | 8 | 99 | |||||
Items per page:
1 – 5 of 62
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 13 | 99.7 | |||||
hemoglobin measurement | 7 | 99.4 | |||||
hematocrit | 10 | 99.3 | |||||
mean corpuscular hemoglobin concentration | 15 | 99.1 | |||||
mean corpuscular volume | 8 | 99 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histone cluster 1 H1 family member a | VGNC:14359 | 471874 | |||||
Mouse | MGI:1931523 | 80838 | ||||||
Rat | RGD:1305706 | 291145 | ||||||
Dog | histone H1.1 | 488258 | ||||||
Horse | histone H1.1 | 100052966 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histone cluster 1 H1 family member a | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone H1.1 | |||||
Horse | histone H1.1 | |||||
Publication Statistics
PubMed Score 811.32
PubMed score by year
PubTator Score 176.48
PubTator score by year
Related Publications
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Text |
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