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Tdark
HIRIP3
HIRA-interacting protein 3

Protein Summary
Description
May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279392
  • ENSP00000279392
  • ENSG00000149929
  • ENST00000564026
  • ENSP00000456824
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
kinase perturbation
0.88
histone modification site profile
0.86
transcription factor binding site profile
0.79
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.999929523
p_ni:  0.000070477
Score:  0.379
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.99989827
p_ni:  0.000007336
p_wrong:  0.000094394
Score:  0.365
Data Source:  BioPlex,STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.99966175
p_ni:  0.00033825
Data Source:  BioPlex
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.998971465
p_ni:  0.001027514
p_wrong:  0.000001021
Data Source:  BioPlex
RIOX2
Tbio
Family:  Epigenetic
Novelty:  0.03254245
p_int:  0.998933528
p_ni:  0.001066421
p_wrong:  5.1e-8
Data Source:  BioPlex
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.99780089
p_ni:  0.00219911
Data Source:  BioPlex
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.994901494
p_ni:  0.000744469
p_wrong:  0.004354038
Score:  0.379
Data Source:  BioPlex,STRINGDB
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
p_int:  0.971588765
p_ni:  0.028411234
Data Source:  BioPlex
HIRA
Tbio
Novelty:  0.01362595
Score:  0.789
Data Source:  STRINGDB
HIST1H2BK
Tbio
Novelty:  0.12867647
Score:  0.755
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
5
6
96.4
appendicular lean mass
2
3
6
94.7
mean corpuscular volume
3
2
3
94
waist-hip ratio
3
3
3
89.1
red blood cell density measurement
2
1
2
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
96.4
appendicular lean mass
6
94.7
mean corpuscular volume
3
94
waist-hip ratio
3
89.1
red blood cell density measurement
2
87.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HIRA interacting protein 3
VGNC:5783
738777
Macaque
HIRA interacting protein 3
708004
Mouse
MGI:2142364
233876
Rat
RGD:1306463
361650
Dog
HIRA interacting protein 3
VGNC:41696
479786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HIRA interacting protein 3
Macaque
HIRA interacting protein 3
Mouse
Rat
Dog
HIRA interacting protein 3
Publication Statistics
PubMed Score 2.82
PubMed score by year
PubTator Score 1.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title