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Tchem
HINT1
Histidine triad nucleotide-binding protein 1

Protein Summary
Description
Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304043
  • ENSP00000304229
  • ENSG00000169567

Symbol
  • HINT
  • PKCI1
  • PRKCNH1
  • HINT
  • NMAN
  • PKCI-1
  • PRKCNH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
virus perturbation
0.94
transcription factor binding site profile
0.93
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.57   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.57   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (227)
CAMKK2
Tchem
Family:  Kinase
Novelty:  0.00426898
p_int:  0.999999909
p_ni:  9.1e-8
Data Source:  BioPlex
ZNF131
Tbio
Family:  TF
Novelty:  0.18894578
p_int:  0.999995955
p_ni:  0.000003781
p_wrong:  2.64e-7
Data Source:  BioPlex
OGA
Tchem
Family:  Enzyme
Novelty:  0.00035723
p_int:  0.99967853
p_ni:  0.00032147
Data Source:  BioPlex
AMMECR1
Tbio
Novelty:  0.12679247
p_int:  0.999580646
p_ni:  0.000009851
p_wrong:  0.000409503
Data Source:  BioPlex
HDAC7
Tclin
Family:  Epigenetic
Novelty:  0.00600484
p_int:  0.99676909
p_ni:  0.00323091
Score:  0.485
Data Source:  BioPlex,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
p_int:  0.982813719
p_ni:  0.01718627
p_wrong:  1.1e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
HINT3
Tdark
Novelty:  1.14285714
p_int:  0.981781392
p_ni:  0.018218596
p_wrong:  1.2e-8
Score:  0.664
Data Source:  BioPlex,STRINGDB
SFTPA2
Tbio
Novelty:  0.00283745
p_int:  0.975206642
p_ni:  0.024793358
Data Source:  BioPlex
SNX24
Tdark
Novelty:  0.20838126
p_int:  0.964485087
p_ni:  0.035514836
p_wrong:  7.7e-8
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.959122459
p_ni:  0.040877541
Score:  0.202
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
80.4
1
1
0
1.1
75.7
lymphocyte count
1
1
1
47.7
high density lipoprotein cholesterol measurement
1
1
1
40.7
mosquito bite reaction itch intensity measurement
1
1
1
28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
80.4
0
1.1
75.7
lymphocyte count
1
47.7
high density lipoprotein cholesterol measurement
1
40.7
mosquito bite reaction itch intensity measurement
1
28
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histidine triad nucleotide binding protein 1
VGNC:14159
462040
Macaque
histidine triad nucleotide binding protein 1
706083
Mouse
MGI:1321133
15254
Rat
Dog
histidine triad nucleotide binding protein 1
474667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histidine triad nucleotide binding protein 1
Macaque
histidine triad nucleotide binding protein 1
Mouse
Rat
Dog
histidine triad nucleotide binding protein 1
Publication Statistics
PubMed Score 112.57
PubMed score by year
PubTator Score 345.01
PubTator score by year
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Related Publications
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PMID
Year
Title