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Tbio
HIF1AN
Hypoxia-inducible factor 1-alpha inhibitor

Protein Summary
Description
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299163
  • ENSP00000299163
  • ENSG00000166135

Symbol
  • FIH1
  • FIH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
biological process
0.84
transcription factor binding site profile
0.78
microRNA
0.75
tissue sample
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.95   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.95   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (134)
APBA3
Tbio
Novelty:  0.05059532
p_int:  1
Score:  0.832
Data Source:  BioPlex,STRINGDB
NFKBIB
Tbio
Novelty:  0.00517222
p_int:  1
Score:  0.606
Data Source:  BioPlex,STRINGDB
CASKIN1
Tdark
Novelty:  0.18266217
p_int:  1
Score:  0.336
Data Source:  BioPlex,STRINGDB
OTUD7B
Tbio
Novelty:  0.0136028
p_int:  0.999999998
p_ni:  2e-9
Score:  0.253
Data Source:  BioPlex,STRINGDB
ANKRD49
Tbio
Novelty:  0.00254346
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.449
Data Source:  BioPlex,STRINGDB
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.99999997
p_ni:  2.2e-8
p_wrong:  8e-9
Score:  0.377
Data Source:  BioPlex,STRINGDB
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.999999935
p_ni:  6.5e-8
Score:  0.908
Data Source:  BioPlex,STRINGDB
ANKRD27
Tbio
Novelty:  0.02843267
p_int:  0.999999626
p_ni:  3.7e-7
p_wrong:  4e-9
Score:  0.248
Data Source:  BioPlex,STRINGDB
FYCO1
Tbio
Novelty:  0.06181219
p_int:  0.999999578
p_ni:  4.22e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
p_int:  0.999999305
p_ni:  6.95e-7
p_wrong:  1e-9
Score:  0.375
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Cellular response to hypoxia (R-HSA-1234174)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to exercise
2
3
3
86
body mass index
7
2
9
86
fatty acid measurement
3
3
3
76.7
maximal oxygen uptake measurement
2
2
2
71.2
systolic blood pressure
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to exercise
3
86
body mass index
9
86
fatty acid measurement
3
76.7
maximal oxygen uptake measurement
2
71.2
systolic blood pressure
1
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hypoxia inducible factor 1 subunit alpha inhibitor
VGNC:12343
466183
Macaque
hypoxia inducible factor 1 alpha subunit inhibitor
710425
Mouse
MGI:2442345
319594
Rat
RGD:1308281
309434
Dog
hypoxia inducible factor 1 subunit alpha inhibitor
VGNC:41687
609221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hypoxia inducible factor 1 subunit alpha inhibitor
Macaque
hypoxia inducible factor 1 alpha subunit inhibitor
Mouse
Rat
Dog
hypoxia inducible factor 1 subunit alpha inhibitor
Publication Statistics
PubMed Score 126.95
PubMed score by year
PubTator Score 52.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title