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Tbio
HIC2
Hypermethylated in cancer 2 protein

Protein Summary
Description
Transcriptional repressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407464
  • ENSP00000385319
  • ENSG00000169635
  • ENST00000407598
  • ENSP00000384889
  • ENST00000443632
  • ENSP00000387757

Symbol
  • HRG22
  • KIAA1020
  • ZBTB30
  • HRG22
  • ZBTB30
  • ZNF907
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.84
interacting protein
0.73
microRNA
0.69
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
E4F1
Tbio
Family:  TF
Novelty:  0.02192338
p_int:  0.999999582
p_ni:  4.18e-7
Data Source:  BioPlex
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.999998884
p_ni:  0.000001116
Score:  0.353
Data Source:  BioPlex,STRINGDB
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.999212526
p_ni:  0.000787474
Data Source:  BioPlex
MCF2L2
Tbio
Novelty:  0.0545344
p_int:  0.996444241
p_ni:  0.003555756
p_wrong:  3e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
TBCCD1
Tbio
Novelty:  0.21991508
p_int:  0.980179024
p_ni:  0.019712834
p_wrong:  0.000108142
Score:  0.157
Data Source:  BioPlex,STRINGDB
YY1AP1
Tbio
Novelty:  0.06862573
p_int:  0.975515723
p_ni:  0.023179552
p_wrong:  0.001304725
Score:  0.194
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.973836156
p_ni:  0.026163766
p_wrong:  7.8e-8
Data Source:  BioPlex
ZNF169
Tdark
Family:  TF
Novelty:  1.09432767
p_int:  0.968887258
p_ni:  0.029676113
p_wrong:  0.00143663
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.955704489
p_ni:  0.044294813
p_wrong:  6.98e-7
Data Source:  BioPlex
CALU
Tbio
Novelty:  0.01285123
p_int:  0.808319625
p_ni:  0.175428987
p_wrong:  0.016251388
Score:  0.282
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
19.6
reticulocyte measurement
2
1
2
14.6
reticulocyte count
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
19.6
reticulocyte measurement
2
14.6
reticulocyte count
1
2.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
HIC ZBTB transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:18595]
Mouse
MGI:1929869
58180
Rat
RGD:1305338
287940
Dog
HIC ZBTB transcriptional repressor 2
VGNC:41684
486444
Horse
HIC ZBTB transcriptional repressor 2
VGNC:18780
100051007
Species
Name
OMA
EggNOG
Inparanoid
Macaque
HIC ZBTB transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:18595]
Mouse
Rat
Dog
HIC ZBTB transcriptional repressor 2
Horse
HIC ZBTB transcriptional repressor 2
Publication Statistics
PubMed Score 8.84
PubMed score by year
PubTator Score 4.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title