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Tbio
HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Protein Summary
Description
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. This gene encodes the enzyme responsible for hydrolysis of both HIBYL-CoA and beta-hydroxypropionyl-CoA. Mutations in this gene have been associated with 3-hyroxyisobutyryl-CoA hydrolase deficiency. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359678
  • ENSP00000352706
  • ENSG00000198130
  • ENST00000392332
  • ENSP00000376144

Symbol
  • HIBYLCOAH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
cellular component
0.62
tissue sample
0.62
transcription factor perturbation
0.61
kinase perturbation
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.15   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.15   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (154)
TMEM184A
Tbio
Novelty:  0.16408207
p_int:  0.999990364
p_ni:  0.000009636
Score:  0.181
Data Source:  BioPlex,STRINGDB
GATC
Tbio
Family:  Enzyme
Novelty:  0.62484697
p_int:  0.999768225
p_ni:  0.000231775
Score:  0.158
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.993018885
p_ni:  0.006981115
Data Source:  BioPlex
ACADVL
Tbio
Family:  Enzyme
Novelty:  0.00383705
p_int:  0.991082513
p_ni:  0.008917487
Score:  0.845
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.935607269
p_ni:  0.064392731
Score:  0.632
Data Source:  BioPlex,STRINGDB
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.894655673
p_ni:  0.104935713
p_wrong:  0.000408614
Data Source:  BioPlex
ATP11B
Tbio
Family:  Transporter
Novelty:  0.08604515
p_int:  0.879587646
p_ni:  0.120412235
p_wrong:  1.18e-7
Data Source:  BioPlex
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
p_int:  0.811599038
p_ni:  0.188400962
Data Source:  BioPlex
MKRN2
Tbio
Family:  Enzyme
Novelty:  0.14061051
p_int:  0.805842127
p_ni:  0.00811732
p_wrong:  0.186040553
Score:  0.209
Data Source:  BioPlex,STRINGDB
HIBADH
Tbio
Family:  Enzyme
Novelty:  0.03861647
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (27)
Branched-chain amino acid catabolism (R-HSA-70895)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
1
1
58.4
reticulocyte measurement
2
1
2
50.6
reticulocyte count
2
1
2
48.5
platelet count
1
1
1
47.7
insomnia measurement
2
1
0
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
58.4
reticulocyte measurement
2
50.6
reticulocyte count
2
48.5
platelet count
1
47.7
insomnia measurement
0
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
3-hydroxyisobutyryl-CoA hydrolase
713951
Mouse
MGI:1923792
227095
Rat
RGD:1308392
301384
Dog
3-hydroxyisobutyryl-CoA hydrolase
607040
Horse
3-hydroxyisobutyryl-CoA hydrolase
VGNC:51457
100069399
Species
Name
OMA
EggNOG
Inparanoid
Macaque
3-hydroxyisobutyryl-CoA hydrolase
Mouse
Rat
Dog
3-hydroxyisobutyryl-CoA hydrolase
Horse
3-hydroxyisobutyryl-CoA hydrolase
Publication Statistics
PubMed Score 38.15
PubMed score by year
PubTator Score 17.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title