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Tdark
HHIPL1
HHIP-like protein 1

Protein Summary
Description
This gene encodes a protein that belongs to the glucose/sorbosone dehydrogenase family. The encoded protein also contains a domain that binds folate and reduced folic acid derivatives. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330710
  • ENSP00000330601
  • ENSG00000182218
  • ENST00000357223
  • ENSP00000349757

Symbol
  • HHIP2
  • KIAA1822
  • UNQ9245
  • KIAA1822
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
PubMedID
0.65
histone modification site profile
0.62
tissue sample
0.55
microRNA
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
p_int:  0.998908318
p_ni:  0.001091578
p_wrong:  1.04e-7
Data Source:  BioPlex
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.966121992
p_ni:  0.033438359
p_wrong:  0.000439649
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.957580997
p_ni:  0.042318919
p_wrong:  0.000100085
Data Source:  BioPlex
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.957116134
p_ni:  0.02554453
p_wrong:  0.017339336
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.952692349
p_ni:  0.047307651
Data Source:  BioPlex
ACOT9
Tbio
Family:  Enzyme
Novelty:  0.17405187
p_int:  0.932512124
p_ni:  0.06748777
p_wrong:  1.06e-7
Data Source:  BioPlex
SEC24B
Tbio
Novelty:  0.01031644
p_int:  0.897289101
p_ni:  0.102710899
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.80080398
p_ni:  0.19919602
Data Source:  BioPlex
CDC7
Tchem
Family:  Kinase
Novelty:  0.00435359
p_int:  0.760184018
p_ni:  0.239815982
Data Source:  BioPlex
BDKRB1
Tchem
Family:  GPCR
Novelty:  0.00625504
Score:  0.686
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
5
4
1.1
91.4
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
91.4
0
1.1
31.4
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HHIP like 1
VGNC:12782
100613836
Macaque
HHIP like 1
717012
Mouse
MGI:1919265
214305
Rat
RGD:1311698
362781
Dog
HHIP like 1
VGNC:53497
612500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HHIP like 1
Macaque
HHIP like 1
Mouse
Rat
Dog
HHIP like 1
Publication Statistics
PubMed Score 1.84
PubMed score by year
PubTator Score 0.97
PubTator score by year
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Related Publications
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PMID
Year
Title