Tdark HHIPL1 HHIP-like protein 1

Protein Summary

Description

This gene encodes a protein that belongs to the glucose/sorbosone dehydrogenase family. The encoded protein also contains a domain that binds folate and reduced folic acid derivatives. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q96JK4
• A2RUF8
• B2RN09
• Q6UXX2

Gene Name

• HHIPL1

Ensembl ID

• ENST00000330710
• ENSP00000330601
• ENSG00000182218
• ENST00000357223
• ENSP00000349757

Symbol

• HHIP2
• KIAA1822
• UNQ9245
• KIAA1822

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
PubMedID	0.65
histone modification site profile	0.62
tissue sample	0.55
microRNA	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (44)

Explore Interacting Targets

1 – 10 of 44

• See Interactions on String-DB

ITPA

Tbio

Family:  Enzyme

Novelty:  0.00235169

p_int:  0.998908318

p_ni:  0.001091578

p_wrong:  1.04e-7

Data Source:  BioPlex

DHRS4

Tbio

Family:  Enzyme

Novelty:  0.02992279

p_int:  0.966121992

p_ni:  0.033438359

p_wrong:  0.000439649

Data Source:  BioPlex

MAP7

Tbio

Novelty:  0.01976296

p_int:  0.957580997

p_ni:  0.042318919

p_wrong:  0.000100085

Data Source:  BioPlex

DDX11

Tbio

Family:  Enzyme

Novelty:  0.02282234

p_int:  0.957116134

p_ni:  0.02554453

p_wrong:  0.017339336

Data Source:  BioPlex

HSPA5

Tchem

Novelty:  0.00043424

p_int:  0.952692349

p_ni:  0.047307651

Data Source:  BioPlex

ACOT9

Tbio

Family:  Enzyme

Novelty:  0.17405187

p_int:  0.932512124

p_ni:  0.06748777

p_wrong:  1.06e-7

Data Source:  BioPlex

SEC24B

Tbio

Novelty:  0.01031644

p_int:  0.897289101

p_ni:  0.102710899

Data Source:  BioPlex

TUBB8

Tclin

Novelty:  0.06403117

p_int:  0.80080398

p_ni:  0.19919602

Data Source:  BioPlex

CDC7

Tchem

Family:  Kinase

Novelty:  0.00435359

p_int:  0.760184018

p_ni:  0.239815982

Data Source:  BioPlex

BDKRB1

Tchem

Family:  GPCR

Novelty:  0.00625504

Score:  0.686

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
catalytic activity	Inferred from Electronic Annotation (IEA)	InterPro
scavenger receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	8	5	4	1.1	91.4
myocardial infarction	EFO_0000612	1	1	0	1.1	31.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	4	1.1	91.4
myocardial infarction	EFO_0000612	0	1.1	31.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
coronary artery disease
myocardial infarction

MGI Phenotype Find Similar Targets

No Header	No Header
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	HHIP like 1	VGNC:12782	100613836
Macaque	HHIP like 1		717012
Mouse	hedgehog interacting protein-like 1	MGI:1919265	214305
Rat	HHIP-like 1	RGD:1311698	362781
Dog	HHIP like 1	VGNC:53497	612500

Species	Name	OMA	EggNOG	Inparanoid
Chimp	HHIP like 1
Macaque	HHIP like 1
Mouse	hedgehog interacting protein-like 1
Rat	HHIP-like 1
Dog	HHIP like 1

Publication Statistics

PubMed Score 1.84

PubMed score by year

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PubTator Score 0.97

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title