HHIP
Hedgehog-interacting protein
Protein Summary
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]
- ENST00000296575
- ENSP00000296575
- ENSG00000164161
- ENST00000434550
- ENSP00000408587
- HIP
- HIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.98 | ||
kinase perturbation | 0.88 | ||
protein domain | 0.85 | ||
PubMedID | 0.74 | ||
disease | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.04 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 215 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.04 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 215 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (65)
Nearest Tclin Targets
Pathways (23)
Reactome (5)
KEGG (4)
PathwayCommons (3)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Reactome | Hedgehog 'on' state | ||||
Reactome | Ligand-receptor interactions | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Hedgehog | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Hedgehog 'on' state | ||||
Ligand-receptor interactions | ||||
Signal Transduction | ||||
Signaling by Hedgehog | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (6)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (34)
Items per page:
1 – 5 of 34
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 9 | 7 | 11 | 8.3 | 98.8 | ||||
BMI-adjusted hip circumference | 3 | 26 | 32 | 98.8 | |||||
FEV/FEC ratio | 2 | 5 | 5 | 98.6 | |||||
forced expiratory volume | 3 | 4 | 3 | 1.2 | 95.6 | ||||
BMI-adjusted waist circumference | 6 | 12 | 24 | 93.4 | |||||
Items per page:
1 – 5 of 34
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 11 | 8.3 | 98.8 | ||||
BMI-adjusted hip circumference | 32 | 98.8 | |||||
FEV/FEC ratio | 5 | 98.6 | |||||
forced expiratory volume | 3 | 1.2 | 95.6 | ||||
BMI-adjusted waist circumference | 24 | 93.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hedgehog interacting protein | VGNC:612 | 461521 | |||||
Macaque | hedgehog interacting protein | 701205 | ||||||
Mouse | MGI:1341847 | 15245 | ||||||
Rat | RGD:1564108 | 291936 | ||||||
Dog | hedgehog interacting protein | VGNC:41681 | 100855424 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hedgehog interacting protein | |||||
Macaque | hedgehog interacting protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | hedgehog interacting protein | |||||
Publication Statistics
PubMed Score 102.04
PubMed score by year
PubTator Score 51.83
PubTator score by year
Related Publications
Text Mined References (74)
GeneRif Annotations (49)
Items per page:
0 of 0
PMID | Year | Title |
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