HHIP
Hedgehog-interacting protein
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.98 | ||
kinase perturbation | 0.88 | ||
protein domain | 0.85 | ||
PubMedID | 0.74 | ||
disease | 0.66 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Reactome | Hedgehog 'on' state | ||||
Reactome | Ligand-receptor interactions | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Hedgehog | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Hedgehog 'on' state | ||||
Ligand-receptor interactions | ||||
Signal Transduction | ||||
Signaling by Hedgehog | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 9 | 7 | 11 | 8.3 | 98.8 | ||||
BMI-adjusted hip circumference | 3 | 26 | 32 | 98.8 | |||||
FEV/FEC ratio | 2 | 5 | 5 | 98.6 | |||||
forced expiratory volume | 3 | 4 | 3 | 1.2 | 95.6 | ||||
BMI-adjusted waist circumference | 6 | 12 | 24 | 93.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 11 | 8.3 | 98.8 | ||||
BMI-adjusted hip circumference | 32 | 98.8 | |||||
FEV/FEC ratio | 5 | 98.6 | |||||
forced expiratory volume | 3 | 1.2 | 95.6 | ||||
BMI-adjusted waist circumference | 24 | 93.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | hedgehog interacting protein | VGNC:612 | 461521 | |||||
Macaque | hedgehog interacting protein | 701205 | ||||||
Mouse | MGI:1341847 | 15245 | ||||||
Rat | RGD:1564108 | 291936 | ||||||
Dog | hedgehog interacting protein | VGNC:41681 | 100855424 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | hedgehog interacting protein | |||||
Macaque | hedgehog interacting protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | hedgehog interacting protein | |||||
PMID | Year | Title |
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