Protein Summary
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in t ...more
- ENST00000222390
- ENSP00000222390
- ENSG00000019991
- ENST00000423064
- ENSP00000413829
- ENST00000444829
- ENSP00000389854
- ENST00000453411
- ENSP00000408270
- ENST00000457544
- ENSP00000391238
- ENST00000644543
- ENSP00000494899
- HPTA
- SF
- HGFB
- HPTA
- F-TCF
- DFNB39
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
protein domain | 1 | ||
PubMedID | 1 | ||
kinase perturbation | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3424.17 (req: < 5)
Gene RIFs: 635 (req: <= 3)
Antibodies: 919 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3424.17 (req: >= 5)
Gene RIFs: 635 (req: > 3)
Antibodies: 919 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 46
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (458)
FKBP7
Family: Enzyme
Novelty: 0.00572565
p_int: 0.764246759
p_ni: 0.235753241
Score: 0.538
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (19)
Downstream (19)
1 – 5 of 19
PDGFRA
Pathways (108)
Reactome (36)
KEGG (13)
PathwayCommons (15)
WikiPathways (44)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | FLT3 Signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
FLT3 Signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (50)
Functions (8)
Components (4)
Processes (38)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 7 | 90.9 | |||||
testosterone measurement | 1 | 1 | 1 | 3.5 | |||||
parental genotype effect measurement | 1 | 1 | 0 | 1.7 | 1.3 | ||||
spontaneous preterm birth | 1 | 1 | 0 | 1.7 | 1.3 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 7 | 90.9 | |||||
testosterone measurement | 1 | 3.5 | |||||
parental genotype effect measurement | 0 | 1.7 | 1.3 | ||||
spontaneous preterm birth | 0 | 1.7 | 1.3 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hepatocyte growth factor | VGNC:7392 | 463503 | |||||
Macaque | hepatocyte growth factor | 708316 | ||||||
Mouse | MGI:96079 | 15234 | ||||||
Rat | RGD:2794 | 24446 | ||||||
Dog | hepatocyte growth factor | VGNC:41674 | 403441 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hepatocyte growth factor | |||||
Macaque | hepatocyte growth factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | hepatocyte growth factor | |||||
Publication Statistics
PubMed Score 3424.17
PubMed score by year
PubTator Score 2837.74
PubTator score by year
Related Publications
Text Mined References (711)
GeneRif Annotations (635)
Items per page:
0 of 0
PMID | Year | Title |
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