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Tchem
HGF
Hepatocyte growth factor

Protein Summary
Description
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222390
  • ENSP00000222390
  • ENSG00000019991
  • ENST00000423064
  • ENSP00000413829
  • ENST00000444829
  • ENSP00000389854
  • ENST00000453411
  • ENSP00000408270
  • ENST00000457544
  • ENSP00000391238
  • ENST00000644543
  • ENSP00000494899

Symbol
  • HPTA
  • SF
  • HGFB
  • HPTA
  • F-TCF
  • DFNB39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
protein domain
1
PubMedID
1
kinase perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3781.47   (req: < 5)
Gene RIFs: 635   (req: <= 3)
Antibodies: 919   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3781.47   (req: >= 5)
Gene RIFs: 635   (req: > 3)
Antibodies: 919   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0