Tbio HEY1 Hairy/enhancer-of-split related with YRPW motif protein 1

Protein Summary

Description

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5J3
• B2R883
• Q5TZS3
• Q8NAM2
• Q9NYP4

Gene Name

• HEY1

Ensembl ID

• ENST00000337919
• ENSP00000338272
• ENSG00000164683
• ENST00000354724
• ENSP00000346761

Symbol

• BHLHB31
• CHF2
• HERP2
• HESR1
• HRT1
• CHF2
• OAF1
• HERP2
• HESR1
• HRT-1
• NERP2
• hHRT1
• BHLHb31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
biological process	0.99
PubMedID	0.84
transcription factor perturbation	0.84
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / ... / Basic Helix-loop-helix Transcription Factor / Hairy/enhancer-of-split Related With Yrpw Motif Protein 1

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Hairy/enhancer-of-split Related With Yrpw Motif Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 231.2   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 383   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 231.2   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0