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Tbio
HEXIM2
Protein HEXIM2

Protein Summary
Description
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307275
  • ENSP00000302276
  • ENSG00000168517
  • ENST00000591576
  • ENSP00000465727
  • ENST00000592695
  • ENSP00000467517

Symbol
  • L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
transcription factor binding site profile
0.94
histone modification site profile
0.73
transcription factor
0.73
virus perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
HEXIM1
Tbio
Novelty:  0.0142443
p_int:  1
Score:  0.828
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  1
Score:  0.313
Data Source:  BioPlex,STRINGDB
CCNT1
Tchem
Novelty:  0.00526848
p_int:  0.999999821
p_ni:  1.79e-7
Score:  0.913
Data Source:  BioPlex,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
p_int:  0.999999569
p_ni:  4.31e-7
Score:  0.953
Data Source:  BioPlex,STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
p_int:  0.999998769
p_ni:  0.000001231
Score:  0.552
Data Source:  BioPlex,STRINGDB
CCNT2
Tbio
Novelty:  0.04593314
p_int:  0.999991027
p_ni:  0.000008973
Score:  0.888
Data Source:  BioPlex,STRINGDB
SURF2
Tdark
Novelty:  0.10662558
p_int:  0.999988858
p_ni:  0.000001514
p_wrong:  0.000009628
Score:  0.499
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999983518
p_ni:  0.000016482
Data Source:  BioPlex
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.999978765
p_ni:  0.000021235
Data Source:  BioPlex
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.999935436
p_ni:  0.000064564
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
3
90.4
BMI-adjusted hip circumference
1
8
8
87.4
hip circumference
1
3
3
86
white matter hyperintensity measurement
2
2
2
83.2
platelet crit
1
2
2
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
90.4
BMI-adjusted hip circumference
8
87.4
hip circumference
3
86
white matter hyperintensity measurement
2
83.2
platelet crit
2
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hexamethylene bisacetamide inducible 2
VGNC:9434
454747
Macaque
hexamethylene bisacetamide inducible 2
716047
Mouse
MGI:1918309
71059
Rat
RGD:1311635
303580
Dog
hexamethylene bisacetamide inducible 2 [Source:HGNC Symbol;Acc:HGNC:28591]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hexamethylene bisacetamide inducible 2
Macaque
hexamethylene bisacetamide inducible 2
Mouse
Rat
Dog
hexamethylene bisacetamide inducible 2 [Source:HGNC Symbol;Acc:HGNC:28591]
Publication Statistics
PubMed Score 3.43
PubMed score by year
PubTator Score 6.96
PubTator score by year
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Related Publications
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PMID
Year
Title