Protein Summary
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000307275
- ENSP00000302276
- ENSG00000168517
- ENST00000591576
- ENSP00000465727
- ENST00000592695
- ENSP00000467517
- L3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
ligand (protein) perturbation | 0.96 | ||
transcription factor binding site profile | 0.94 | ||
histone modification site profile | 0.73 | ||
transcription factor | 0.73 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.43 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 150 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.43 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 150 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (31)
CCNT1
Novelty: 0.00526848
p_int: 0.999999821
p_ni: 1.79e-7
Score: 0.913
Data Source: BioPlex,STRINGDB
CDK9
Family: Kinase
Novelty: 0.00210218
p_int: 0.999999569
p_ni: 4.31e-7
Score: 0.953
Data Source: BioPlex,STRINGDB
TCF12
Family: TF
Novelty: 0.00381424
p_int: 0.999998769
p_ni: 0.000001231
Score: 0.552
Data Source: BioPlex,STRINGDB
CCNT2
Novelty: 0.04593314
p_int: 0.999991027
p_ni: 0.000008973
Score: 0.888
Data Source: BioPlex,STRINGDB
SURF2
Novelty: 0.10662558
p_int: 0.999988858
p_ni: 0.000001514
p_wrong: 0.000009628
Score: 0.499
Data Source: BioPlex,STRINGDB
CSNK2A2
Family: Kinase
Novelty: 0.00231447
p_int: 0.999983518
p_ni: 0.000016482
Data Source: BioPlex
AHCYL2
Family: Enzyme
Novelty: 0.08695339
p_int: 0.999978765
p_ni: 0.000021235
Data Source: BioPlex
CSNK2A1
Family: Kinase
Novelty: 0.00187855
p_int: 0.999935436
p_ni: 0.000064564
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 2 | 3 | 90.4 | |||||
BMI-adjusted hip circumference | 1 | 8 | 8 | 87.4 | |||||
hip circumference | 1 | 3 | 3 | 86 | |||||
white matter hyperintensity measurement | 2 | 2 | 2 | 83.2 | |||||
platelet crit | 1 | 2 | 2 | 78.7 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 90.4 | |||||
BMI-adjusted hip circumference | 8 | 87.4 | |||||
hip circumference | 3 | 86 | |||||
white matter hyperintensity measurement | 2 | 83.2 | |||||
platelet crit | 2 | 78.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | hexamethylene bisacetamide inducible 2 | VGNC:9434 | 454747 | |||||
Macaque | hexamethylene bisacetamide inducible 2 | 716047 | ||||||
Mouse | MGI:1918309 | 71059 | ||||||
Rat | RGD:1311635 | 303580 | ||||||
Dog | hexamethylene bisacetamide inducible 2 [Source:HGNC Symbol;Acc:HGNC:28591] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | hexamethylene bisacetamide inducible 2 | |||||
Macaque | hexamethylene bisacetamide inducible 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hexamethylene bisacetamide inducible 2 [Source:HGNC Symbol;Acc:HGNC:28591] | |||||
Publication Statistics
PubMed Score 3.43
PubMed score by year
PubTator Score 6.96
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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