Tbio HEXIM2 Protein HEXIM2

Protein Summary

Description

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• Q96MH2
• D3DX66

Gene Name

• HEXIM2

Ensembl ID

• ENST00000307275
• ENSP00000302276
• ENSG00000168517
• ENST00000591576
• ENSP00000465727
• ENST00000592695
• ENSP00000467517

Symbol

• L3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
transcription factor binding site profile	0.94
histone modification site profile	0.73
transcription factor	0.73
virus perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (31)

Explore Interacting Targets

1 – 10 of 31

• See Interactions on String-DB

HEXIM1

Tbio

Novelty:  0.0142443

p_int:  1

Score:  0.828

Data Source:  BioPlex,STRINGDB

TCF4

Tbio

Family:  TF

Novelty:  0.0019718

p_int:  1

Score:  0.313

Data Source:  BioPlex,STRINGDB

CCNT1

Tchem

Novelty:  0.00526848

p_int:  0.999999821

p_ni:  1.79e-7

Score:  0.913

Data Source:  BioPlex,STRINGDB

CDK9

Tchem

Family:  Kinase

Novelty:  0.00210218

p_int:  0.999999569

p_ni:  4.31e-7

Score:  0.953

Data Source:  BioPlex,STRINGDB

TCF12

Tbio

Family:  TF

Novelty:  0.00381424

p_int:  0.999998769

p_ni:  0.000001231

Score:  0.552

Data Source:  BioPlex,STRINGDB

CCNT2

Tbio

Novelty:  0.04593314

p_int:  0.999991027

p_ni:  0.000008973

Score:  0.888

Data Source:  BioPlex,STRINGDB

SURF2

Tdark

Novelty:  0.10662558

p_int:  0.999988858

p_ni:  0.000001514

p_wrong:  0.000009628

Score:  0.499

Data Source:  BioPlex,STRINGDB

CSNK2A2

Tchem

Family:  Kinase

Novelty:  0.00231447

p_int:  0.999983518

p_ni:  0.000016482

Data Source:  BioPlex

AHCYL2

Tbio

Family:  Enzyme

Novelty:  0.08695339

p_int:  0.999978765

p_ni:  0.000021235

Data Source:  BioPlex

CSNK2A1

Tchem

Family:  Kinase

Novelty:  0.00187855

p_int:  0.999935436

p_ni:  0.000064564

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (4)

Components (5)

Processes (3)

Find Similar Targets

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1 – 4 of 4

GO Term	Evidence	Assigned by
7SK snRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
cyclin-dependent protein serine/threonine kinase inhibitor activity	Inferred from Direct Assay (IDA)	HGNC
snRNA binding	Inferred from Direct Assay (IDA)	HGNC
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Disease Associations (null)

No disease associations found

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	3	2	3		90.4
BMI-adjusted hip circumference	EFO_0008039	1	8	8		87.4
hip circumference	EFO_0005093	1	3	3		86
white matter hyperintensity measurement	EFO_0005665	2	2	2		83.2
platelet crit	EFO_0007985	1	2	2		78.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	3		90.4
BMI-adjusted hip circumference	EFO_0008039	8		87.4
hip circumference	EFO_0005093	3		86
white matter hyperintensity measurement	EFO_0005665	2		83.2
platelet crit	EFO_0007985	2		78.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Coiled coil
Complete proteome
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
asthma
balding measurement
BMI-adjusted hip circumference
body height
gait measurement
hip circumference
hypertension
hypothyroidism
insomnia measurement

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	hexamethylene bisacetamide inducible 2	VGNC:9434	454747
Macaque	hexamethylene bisacetamide inducible 2		716047
Mouse	hexamethylene bis-acetamide inducible 2	MGI:1918309	71059
Rat	hexamethylene bis-acetamide inducible 2	RGD:1311635	303580
Dog	hexamethylene bisacetamide inducible 2 [Source:HGNC Symbol;Acc:HGNC:28591]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	hexamethylene bisacetamide inducible 2
Macaque	hexamethylene bisacetamide inducible 2
Mouse	hexamethylene bis-acetamide inducible 2
Rat	hexamethylene bis-acetamide inducible 2
Dog	hexamethylene bisacetamide inducible 2 [Source:HGNC Symbol;Acc:HGNC:28591]

Publication Statistics

PubMed Score 3.43

PubMed score by year

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PubTator Score 6.96

PubTator score by year

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Related Publications

Text Mined References (24)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title