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Tbio
HEXIM1
Protein HEXIM1

Protein Summary
Description
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332499
  • ENSP00000328773
  • ENSG00000186834

Symbol
  • CLP1
  • EDG1
  • HIS1
  • MAQ1
  • CLP1
  • EDG1
  • HIS1
  • MAQ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor binding site profile
0.98
kinase perturbation
0.96
disease perturbation
0.93
transcription factor perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.69   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 422   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.69   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 422   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
HEXIM2
Tbio
Novelty:  0.14814693
p_int:  1
Score:  0.828
Data Source:  BioPlex,STRINGDB
CCNT2
Tbio
Novelty:  0.04593314
p_int:  0.999999864
p_ni:  1.36e-7
Score:  0.968
Data Source:  BioPlex,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
p_int:  0.999999816
p_ni:  1.84e-7
Score:  0.98
Data Source:  BioPlex,STRINGDB
CCNT1
Tchem
Novelty:  0.00526848
p_int:  0.999996905
p_ni:  0.000002929
p_wrong:  1.66e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
OSBPL1A
Tbio
Novelty:  0.12951159
p_int:  0.999995318
p_ni:  0.000004682
Score:  0.19
Data Source:  BioPlex,STRINGDB
MEPCE
Tbio
Novelty:  0.05592081
p_int:  0.999977511
p_ni:  0.000022489
Score:  0.951
Data Source:  BioPlex,STRINGDB
NSMAF
Tbio
Novelty:  0.08595515
p_int:  0.999818449
p_ni:  0.000155823
p_wrong:  0.000025729
Score:  0.27
Data Source:  BioPlex,STRINGDB
SH3BP5L
Tdark
Novelty:  1.7921497
p_int:  0.999076129
p_ni:  0.000923871
Data Source:  BioPlex
SURF2
Tdark
Novelty:  0.10662558
p_int:  0.998673734
p_ni:  0.001325901
p_wrong:  3.65e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.997723524
p_ni:  0.002276476
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Initiation of transcription and translation elongation at the HIV-1 LTR
WikiPathways
Initiation of transcription and translation elongation at the HIV-1 LTR
WikiPathways
Initiation of transcription and translation elongation at the HIV-1 LTR
WikiPathways
Initiation of transcription and translation elongation at the HIV-1 LTR
WikiPathways
Initiation of transcription and translation elongation at the HIV-1 LTR
Name
Explore in Pharos
Explore in Source
Initiation of transcription and translation elongation at the HIV-1 LTR
Initiation of transcription and translation elongation at the HIV-1 LTR
Initiation of transcription and translation elongation at the HIV-1 LTR
Initiation of transcription and translation elongation at the HIV-1 LTR
Initiation of transcription and translation elongation at the HIV-1 LTR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
5
4
4
8.1
94.7
appendicular lean mass
3
3
3
94.3
insomnia measurement
3
3
0
1
91
body height
3
1
3
89.3
BMI-adjusted hip circumference
2
10
11
80.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
4
8.1
94.7
appendicular lean mass
3
94.3
insomnia measurement
0
1
91
body height
3
89.3
BMI-adjusted hip circumference
11
80.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2385923
192231
Rat
RGD:1559851
498008
Dog
hexamethylene bisacetamide inducible 1
VGNC:41670
606811
Horse
hexamethylene bisacetamide inducible 1
VGNC:18761
100050208
Cow
hexamethylene bisacetamide inducible 1
VGNC:29826
539696
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
hexamethylene bisacetamide inducible 1
Horse
hexamethylene bisacetamide inducible 1
Cow
hexamethylene bisacetamide inducible 1
Publication Statistics
PubMed Score 99.69
PubMed score by year
PubTator Score 62.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title