Tbio HEXD Hexosaminidase D

Protein Summary

Description

Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221).

Uniprot Accession IDs

• Q8WVB3
• B7UUP6
• Q8IYN4
• Q8TE81

Gene Name

• HEXD

Ensembl ID

• ENST00000327949
• ENSP00000332634
• ENSG00000169660
• ENST00000337014
• ENSP00000337854
• ENST00000644009
• ENSP00000496193

Symbol

• HEXDC
• HEXDC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.66
transcription factor binding site profile	0.59
tissue sample	0.58
cellular component	0.55
transcription factor	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.9   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.9   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0