You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HEXD
Hexosaminidase D

Protein Summary
Description
Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327949
  • ENSP00000332634
  • ENSG00000169660
  • ENST00000337014
  • ENSP00000337854
  • ENST00000644009
  • ENSP00000496193

Symbol
  • HEXDC
  • HEXDC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.66
transcription factor binding site profile
0.59
tissue sample
0.58
cellular component
0.55
transcription factor
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.77   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.77   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
HEXA
Tchem
Family:  Enzyme
Novelty:  0.01134783
Score:  0.94
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.919
Data Source:  STRINGDB
YPEL5
Tbio
Novelty:  0.26093125
Score:  0.697
Data Source:  STRINGDB
OGA
Tchem
Family:  Enzyme
Novelty:  0.00035723
Score:  0.672
Data Source:  STRINGDB
ZNF662
Tdark
Family:  TF
Novelty:  2.52868181
Score:  0.602
Data Source:  STRINGDB
FAM198A
Tdark
Novelty:  0.65293749
Score:  0.58
Data Source:  STRINGDB
ARMC7
Tdark
Novelty:  0.24695796
Score:  0.565
Data Source:  STRINGDB
KIN
Tbio
Novelty:  0.01425955
Score:  0.516
Data Source:  STRINGDB
GANC
Tchem
Family:  Enzyme
Novelty:  0.02123234
Score:  0.514
Data Source:  STRINGDB
INTS2
Tdark
Novelty:  0.22178745
Score:  0.509
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Various types of N-glycan biosynthesis
KEGG
Other glycan degradation
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Various types of N-glycan biosynthesis
Other glycan degradation
Metabolic pathways
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
3
93.7
reticulocyte count
3
2
3
83.4
red blood cell distribution width
4
1
4
81.9
mean corpuscular hemoglobin concentration
1
1
1
73.2
reticulocyte measurement
2
1
2
72.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
93.7
reticulocyte count
3
83.4
red blood cell distribution width
4
81.9
mean corpuscular hemoglobin concentration
1
73.2
reticulocyte measurement
2
72.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 21.77
PubMed score by year
PubTator Score 39.58
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title