Protein Summary
Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221).
- ENST00000327949
- ENSP00000332634
- ENSG00000169660
- ENST00000337014
- ENSP00000337854
- ENST00000644009
- ENSP00000496193
- HEXDC
- HEXDC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.66 | ||
transcription factor binding site profile | 0.59 | ||
tissue sample | 0.58 | ||
cellular component | 0.55 | ||
transcription factor | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.77 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 73 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.77 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 73 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (27)
Nearest Tclin Targets
Pathways (3)
KEGG (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Various types of N-glycan biosynthesis | ||||
KEGG | Other glycan degradation | ||||
KEGG | Metabolic pathways | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Various types of N-glycan biosynthesis | ||||
Other glycan degradation | ||||
Metabolic pathways | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (3)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 3 | 3 | 93.7 | |||||
reticulocyte count | 3 | 2 | 3 | 83.4 | |||||
red blood cell distribution width | 4 | 1 | 4 | 81.9 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 73.2 | |||||
reticulocyte measurement | 2 | 1 | 2 | 72.6 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 93.7 | |||||
reticulocyte count | 3 | 83.4 | |||||
red blood cell distribution width | 4 | 81.9 | |||||
mean corpuscular hemoglobin concentration | 1 | 73.2 | |||||
reticulocyte measurement | 2 | 72.6 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 21.77
PubMed score by year
PubTator Score 39.58
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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