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Tbio
HESX1
Homeobox expressed in ES cells 1

Protein Summary
Description
Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295934
  • ENSP00000295934
  • ENSG00000163666
  • ENST00000647958
  • ENSP00000498190

Symbol
  • HANF
  • ANF
  • RPX
  • CPHD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.79
virus perturbation
0.79
PubMedID
0.67
gene perturbation
0.6
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.15   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.15   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
RBP4
Tchem
Novelty:  0.00168442
p_int:  0.977421283
p_ni:  0.022578378
p_wrong:  3.39e-7
Score:  0.622
Data Source:  BioPlex,STRINGDB
POU1F1
Tbio
Family:  TF
Novelty:  0.0052029
Score:  0.851
Data Source:  STRINGDB
TBX19
Tbio
Family:  TF
Novelty:  0.01599679
Score:  0.803
Data Source:  STRINGDB
SOX3
Tbio
Family:  TF
Novelty:  0.00280653
Score:  0.719
Data Source:  STRINGDB
TLE3
Tbio
Novelty:  0.02641884
Score:  0.691
Data Source:  STRINGDB
ASB14
Tdark
Novelty:  1.75017246
Score:  0.663
Data Source:  STRINGDB
DNAH12
Tbio
Novelty:  0.02743114
Score:  0.662
Data Source:  STRINGDB
PROKR2
Tchem
Family:  GPCR
Novelty:  0.01400881
Score:  0.652
Data Source:  STRINGDB
TLE1
Tbio
Novelty:  0.00594261
Score:  0.652
Data Source:  STRINGDB
GHRHR
Tclin
Family:  GPCR
Novelty:  0.00637611
Score:  0.648
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
36.9
IGF-1 measurement
1
1
1
5.5
1
1
0
5.7
3.2
family history of Alzheimer’s disease
1
1
0
5.7
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
36.9
IGF-1 measurement
1
5.5
0
5.7
3.2
family history of Alzheimer’s disease
0
5.7
3.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HESX homeobox 1
VGNC:1836
747229
Macaque
HESX homeobox 1
704551
Mouse
MGI:96071
15209
Rat
RGD:1563858
498575
Dog
HESX homeobox 1
VGNC:41668
484718
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HESX homeobox 1
Macaque
HESX homeobox 1
Mouse
Rat
Dog
HESX homeobox 1
Publication Statistics
PubMed Score 123.15
PubMed score by year
PubTator Score 143.94
PubTator score by year
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Related Publications
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PMID
Year
Title