Tbio HESX1 Homeobox expressed in ES cells 1

Protein Summary

Description

Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBX0
• Q52LC5
• Q99667

Gene Name

• HESX1

Ensembl ID

• ENST00000295934
• ENSP00000295934
• ENSG00000163666
• ENST00000647958
• ENSP00000498190

Symbol

• HANF
• ANF
• RPX
• CPHD5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.79
virus perturbation	0.79
PubMedID	0.67
gene perturbation	0.6
tissue sample	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.82   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.82   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0