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Tbio
HES7
Transcription factor HES-7

Protein Summary
Description
Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity). This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317814
  • ENSP00000314774
  • ENSG00000179111
  • ENST00000541682
  • ENSP00000446205

Symbol
  • BHLHB37
  • SCDO4
  • bHLHb37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.75
biological process
0.68
tissue
0.68
gene perturbation
0.59
transcription factor
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.44   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.44   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.954
Data Source:  STRINGDB
GPR153
Tdark
Family:  GPCR
Novelty:  0.44419008
Score:  0.893
Data Source:  STRINGDB
LFNG
Tbio
Family:  Enzyme
Novelty:  0.02660238
Score:  0.839
Data Source:  STRINGDB
TBX6
Tbio
Family:  TF
Novelty:  0.01060902
Score:  0.825
Data Source:  STRINGDB
MESP2
Tbio
Family:  TF
Novelty:  0.02601024
Score:  0.816
Data Source:  STRINGDB
ALOXE3
Tbio
Family:  Enzyme
Novelty:  0.02560954
Score:  0.763
Data Source:  STRINGDB
DLL1
Tbio
Novelty:  0.00150384
Score:  0.761
Data Source:  STRINGDB
DLL3
Tbio
Novelty:  0.00867672
Score:  0.74
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.686
Data Source:  STRINGDB
UTS2R
Tchem
Family:  GPCR
Novelty:  0.00865846
Score:  0.681
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
2
1.1
88.6
high density lipoprotein cholesterol measurement
1
1
1
49.5
diastolic blood pressure
1
1
1
49.5
mitochondrial DNA measurement
1
1
1
14.2
apolipoprotein A 1 measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
88.6
high density lipoprotein cholesterol measurement
1
49.5
diastolic blood pressure
1
49.5
mitochondrial DNA measurement
1
14.2
apolipoprotein A 1 measurement
1
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
hes family bHLH transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:15977]
Mouse
MGI:2135679
84653
Rat
RGD:1305914
287423
Dog
hes family bHLH transcription factor 7
VGNC:41667
612802
Horse
hes family bHLH transcription factor 7
VGNC:18758
100062391
Species
Name
OMA
EggNOG
Inparanoid
Macaque
hes family bHLH transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:15977]
Mouse
Rat
Dog
hes family bHLH transcription factor 7
Horse
hes family bHLH transcription factor 7
Publication Statistics
PubMed Score 54.44
PubMed score by year
PubTator Score 16.66
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title