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Tbio
HES4
Transcription factor HES-4

Protein Summary
Description
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304952
  • ENSP00000304595
  • ENSG00000188290

Symbol
  • BHLHB42
  • bHLHb42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.69
virus perturbation
0.68
tissue sample
0.62
disease
0.55
transcription factor
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.995737049
p_ni:  0.00426061
p_wrong:  0.000002342
Data Source:  BioPlex
SERPINB8
Tbio
Novelty:  0.03308357
p_int:  0.995393751
p_ni:  0.004552245
p_wrong:  0.000054004
Data Source:  BioPlex
PAFAH2
Tbio
Family:  Enzyme
Novelty:  0.19881779
p_int:  0.994708666
p_ni:  0.005291302
p_wrong:  3.2e-8
Data Source:  BioPlex
IL37
Tbio
Novelty:  0.00499186
p_int:  0.987897416
p_ni:  0.009555375
p_wrong:  0.002547209
Data Source:  BioPlex
HAL
Tbio
Family:  Enzyme
Novelty:  0.01504631
p_int:  0.984284326
p_ni:  0.015715664
p_wrong:  1e-8
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.983055821
p_ni:  0.016898846
p_wrong:  0.000045333
Data Source:  BioPlex
GSDMA
Tbio
Novelty:  0.01454503
p_int:  0.977457226
p_ni:  0.022542774
Data Source:  BioPlex
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.976328076
p_ni:  2e-8
p_wrong:  0.023671905
Score:  0.329
Data Source:  BioPlex,STRINGDB
TGM1
Tchem
Family:  Enzyme
Novelty:  0.00103799
p_int:  0.974020018
p_ni:  0.025979982
Data Source:  BioPlex
CTSV
Tchem
Family:  Enzyme
Novelty:  0.00916301
p_int:  0.967128264
p_ni:  0.028461539
p_wrong:  0.004410197
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
59.6
apolipoprotein A 1 measurement
2
2
2
52
high density lipoprotein cholesterol measurement
2
2
2
47.4
alkaline phosphatase measurement
1
1
1
46.9
hip bone size
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
59.6
apolipoprotein A 1 measurement
2
52
high density lipoprotein cholesterol measurement
2
47.4
alkaline phosphatase measurement
1
46.9
hip bone size
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
hes family bHLH transcription factor 4
698434
Cow
hes family bHLH transcription factor 4
VGNC:29821
507480
Species
Name
OMA
EggNOG
Inparanoid
Macaque
hes family bHLH transcription factor 4
Cow
hes family bHLH transcription factor 4
Publication Statistics
PubMed Score 16.44
PubMed score by year
PubTator Score 12.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title