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Tbio
HERC3
Probable E3 ubiquitin-protein ligase HERC3

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264345
  • ENSP00000264345
  • ENSG00000138641
  • ENST00000402738
  • ENSP00000385684
  • ENST00000407637
  • ENSP00000384005

Symbol
  • KIAA0032
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
kinase perturbation
0.81
cell type or tissue
0.62
small molecule perturbation
0.6
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (305)
NUDCD2
Tdark
Novelty:  0.60015068
p_int:  0.996130114
p_ni:  0.003869886
Score:  0.39
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.995451125
p_ni:  0.004548875
Score:  0.202
Data Source:  BioPlex,STRINGDB
LPCAT2
Tbio
Family:  Enzyme
Novelty:  0.02794035
p_int:  0.981839469
p_ni:  0.01816053
p_wrong:  1e-9
Data Source:  BioPlex
POTEC
Tdark
Novelty:  1.98957109
p_int:  0.978766407
p_ni:  0.021233593
Score:  0.196
Data Source:  BioPlex,STRINGDB
ACOX3
Tchem
Family:  Enzyme
Novelty:  0.04077258
p_int:  0.963527521
p_ni:  0.036472479
Score:  0.217
Data Source:  BioPlex,STRINGDB
CYP8B1
Tchem
Family:  Enzyme
Novelty:  0.01243408
p_int:  0.960744849
p_ni:  0.039255151
Score:  0.192
Data Source:  BioPlex,STRINGDB
HSD17B3
Tchem
Family:  Enzyme
Novelty:  0.00666322
p_int:  0.944820796
p_ni:  0.055179204
Data Source:  BioPlex
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
p_int:  0.89329665
p_ni:  0.10670335
Score:  0.287
Data Source:  BioPlex,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.885359711
p_ni:  0.114640289
Data Source:  BioPlex
CYP39A1
Tbio
Family:  Enzyme
Novelty:  0.0556276
p_int:  0.880614612
p_ni:  0.119385388
Score:  0.393
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
15
29
98.6
waist-hip ratio
3
13
14
98.5
waist circumference
1
6
6
93.9
BMI-adjusted waist circumference
1
5
5
93
high density lipoprotein cholesterol measurement
3
4
5
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
29
98.6
waist-hip ratio
14
98.5
waist circumference
6
93.9
BMI-adjusted waist circumference
5
93
high density lipoprotein cholesterol measurement
5
92.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
HECT and RLD domain containing E3 ubiquitin protein ligase 3
703108
Mouse
MGI:1921248
73998
Rat
RGD:1307803
362377
Dog
HECT and RLD domain containing E3 ubiquitin protein ligase 3
VGNC:49907
478475
Horse
HECT and RLD domain containing E3 ubiquitin protein ligase 3
VGNC:49460
100053167
Species
Name
OMA
EggNOG
Inparanoid
Macaque
HECT and RLD domain containing E3 ubiquitin protein ligase 3
Mouse
Rat
Dog
HECT and RLD domain containing E3 ubiquitin protein ligase 3
Horse
HECT and RLD domain containing E3 ubiquitin protein ligase 3
Publication Statistics
PubMed Score 17.59
PubMed score by year
PubTator Score 4.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title