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Tbio
HEPHL1
Hephaestin-like protein 1

Protein Summary
Description
May function as a ferroxidase and may be involved in copper transport and homeostasis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315765
  • ENSP00000313699
  • ENSG00000181333
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.71
cell line
0.58
protein domain
0.58
metabolite
0.45
transcription factor
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999997035
p_ni:  0.000002965
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.999965852
p_ni:  0.000034148
Data Source:  BioPlex
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.999921952
p_ni:  0.000078048
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.999874923
p_ni:  0.000125077
Data Source:  BioPlex
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.999857277
p_ni:  0.000142723
Data Source:  BioPlex
NSMAF
Tbio
Novelty:  0.08595515
p_int:  0.999749473
p_ni:  0.00024951
p_wrong:  0.000001017
Data Source:  BioPlex
FBXO3
Tbio
Novelty:  0.01701102
p_int:  0.999718718
p_ni:  0.000281281
p_wrong:  1e-9
Data Source:  BioPlex
COASY
Tbio
Family:  Enzyme
Novelty:  0.00294867
p_int:  0.999414786
p_ni:  0.000585214
Score:  0.157
Data Source:  BioPlex,STRINGDB
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999383307
p_ni:  0.000616693
Data Source:  BioPlex
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.998991175
p_ni:  0.00100811
p_wrong:  7.15e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
3
3
2
12.8
95.7
serum alanine aminotransferase measurement
3
2
2
15.6
94.7
Thyroid preparation use measurement
1
1
1
46.9
mean corpuscular volume
1
1
1
29
autoimmune thyroid disease
1
1
0
1.1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
12.8
95.7
serum alanine aminotransferase measurement
2
15.6
94.7
Thyroid preparation use measurement
1
46.9
mean corpuscular volume
1
29
autoimmune thyroid disease
0
1.1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hephaestin like 1
VGNC:3252
451487
Mouse
MGI:2685355
244698
Rat
RGD:1564835
500946
Dog
hephaestin like 1
VGNC:41660
485127
Horse
hephaestin like 1
VGNC:18751
100058293
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hephaestin like 1
Mouse
Rat
Dog
hephaestin like 1
Horse
hephaestin like 1
Publication Statistics
PubMed Score 4.18
PubMed score by year
PubTator Score 0.56
PubTator score by year
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Related Publications
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PMID
Year
Title