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Tbio
HEPACAM2
HEPACAM family member 2

Protein Summary
Description
Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341723
  • ENSP00000340532
  • ENSG00000188175
  • ENST00000394468
  • ENSP00000377980
  • ENST00000453812
  • ENSP00000390204

Symbol
  • MIKI
  • MIKI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.86
protein domain
0.85
cell line
0.51
tissue
0.48
transcription factor
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
RELT
Tbio
Novelty:  0.07977949
p_int:  0.996526388
p_ni:  0.003473023
p_wrong:  5.88e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
CYB5R1
Tbio
Family:  Enzyme
Novelty:  0.07714146
p_int:  0.994873332
p_ni:  0.005126668
Data Source:  BioPlex
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
p_int:  0.992706426
p_ni:  0.006073343
p_wrong:  0.001220231
Data Source:  BioPlex
NAT14
Tbio
Family:  Enzyme
Novelty:  0.08842982
p_int:  0.989923067
p_ni:  0.010076933
Data Source:  BioPlex
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.988160061
p_ni:  0.01183978
p_wrong:  1.59e-7
Data Source:  BioPlex
ERO1B
Tbio
Novelty:  0.06389159
p_int:  0.972290463
p_ni:  0.027709536
Data Source:  BioPlex
MFAP3
Tdark
Novelty:  0.55512255
p_int:  0.965297312
p_ni:  0.034702688
Data Source:  BioPlex
LRP10
Tbio
Novelty:  0.04049684
p_int:  0.954902344
p_ni:  0.045097656
p_wrong:  1e-9
Data Source:  BioPlex
PTPRS
Tchem
Family:  Enzyme
Novelty:  0.00587115
p_int:  0.952849913
p_ni:  0.047150087
Data Source:  BioPlex
ACVR2A
Tchem
Family:  Kinase
Novelty:  0.0063932
p_int:  0.946204062
p_ni:  0.05307707
p_wrong:  0.000718868
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
11
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
11
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HEPACAM family member 2
VGNC:14020
463537
Macaque
HEPACAM family member 2
702110
Mouse
MGI:2141520
101202
Rat
RGD:1305697
296846
Dog
HEPACAM family member 2
VGNC:41658
609954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HEPACAM family member 2
Macaque
HEPACAM family member 2
Mouse
Rat
Dog
HEPACAM family member 2
Publication Statistics
PubMed Score 4.89
PubMed score by year
PubTator Score 51.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text