Tbio HEPACAM2 HEPACAM family member 2

Protein Summary

Description

Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• A8MVW5
• B3KTT4
• B4DPJ1
• B9EG93
• E9PDV5
• Q6UXI0

Gene Name

• HEPACAM2

Ensembl ID

• ENST00000341723
• ENSP00000340532
• ENSG00000188175
• ENST00000394468
• ENSP00000377980
• ENST00000453812
• ENSP00000390204

Symbol

• MIKI
• MIKI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.86
protein domain	0.85
cell line	0.51
tissue	0.48
transcription factor	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.35   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.35   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0