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Tbio
HEPACAM
Hepatocyte cell adhesion molecule

Protein Summary
Description
Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation. The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298251
  • ENSP00000298251
  • ENSG00000165478

Symbol
  • HEPN1
  • MLC2A
  • MLC2B
  • GlialCAM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cellular component
0.53
biological term
0.47
tissue
0.45
microRNA
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.38   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.38   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
C1orf87
Tbio
Novelty:  0.03162594
p_int:  0.999990565
p_wrong:  0.000009435
Score:  0.416
Data Source:  BioPlex,STRINGDB
CLCN2
Tclin
Family:  IC
Novelty:  0.00838393
Score:  0.737
Data Source:  STRINGDB
ALDH1L1
Tbio
Family:  Enzyme
Novelty:  0.01123871
Score:  0.657
Data Source:  STRINGDB
CLCN1
Tbio
Family:  IC
Novelty:  0.00287764
Score:  0.657
Data Source:  STRINGDB
ABCD1
Tbio
Family:  Transporter
Novelty:  0.0067013
Score:  0.607
Data Source:  STRINGDB
PHF21B
Tbio
Family:  Epigenetic
Novelty:  0.17016704
Score:  0.594
Data Source:  STRINGDB
LRRC8A
Tbio
Novelty:  0.0163093
Score:  0.584
Data Source:  STRINGDB
TRPV4
Tchem
Family:  IC
Novelty:  0.00111193
Score:  0.554
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.546
Data Source:  STRINGDB
AQP4
Tbio
Novelty:  0.00031632
Score:  0.544
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroimaging measurement
1
1
1
72.2
white matter microstructure measurement
1
1
1
62.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroimaging measurement
1
72.2
white matter microstructure measurement
1
62.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hepatic and glial cell adhesion molecule
VGNC:11808
466840
Mouse
MGI:1920177
72927
Rat
RGD:1306811
300517
Dog
hepatic and glial cell adhesion molecule
VGNC:41657
489305
Horse
hepatic and glial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:26361]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hepatic and glial cell adhesion molecule
Mouse
Rat
Dog
hepatic and glial cell adhesion molecule
Horse
hepatic and glial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:26361]
Publication Statistics
PubMed Score 93.38
PubMed score by year
PubTator Score 38.16
PubTator score by year
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Related Publications
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PMID
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