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Tdark
HENMT1
Small RNA 2'-O-methyltransferase

Protein Summary
Description
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370032
  • ENSP00000359049
  • ENSG00000162639
  • ENST00000402983
  • ENSP00000385655

Symbol
  • C1orf59
  • HEN1
  • C1orf59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
tissue sample
0.67
cell type or tissue
0.66
molecular function
0.56
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
PECR
Tbio
Family:  Enzyme
Novelty:  0.01550165
p_int:  0.999993169
p_ni:  0.000002609
p_wrong:  0.000004222
Score:  0.205
Data Source:  BioPlex,STRINGDB
MTHFD2L
Tdark
Family:  Enzyme
Novelty:  0.18530504
p_int:  0.999963441
p_ni:  0.000036556
p_wrong:  3e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
SNX6
Tbio
Novelty:  0.05909848
p_int:  0.998657275
p_ni:  0.001342718
p_wrong:  7e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.998301484
p_ni:  0.001698516
Score:  0.274
Data Source:  BioPlex,STRINGDB
SNX2
Tbio
Novelty:  0.03880384
p_int:  0.997867296
p_ni:  0.002132704
Score:  0.167
Data Source:  BioPlex,STRINGDB
SBF1
Tbio
Novelty:  0.01814482
p_int:  0.996085568
p_ni:  0.003914431
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.787334632
p_ni:  0.212665367
Score:  0.179
Data Source:  BioPlex,STRINGDB
RAD51C
Tbio
Novelty:  0.0063568
p_int:  0.756103317
p_ni:  0.243896683
Score:  0.228
Data Source:  BioPlex,STRINGDB
PIWIL1
Tbio
Novelty:  0.00095911
Score:  0.977
Data Source:  Reactome,STRINGDB
PIWIL4
Tbio
Novelty:  0.00105088
Score:  0.976
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
2
2
74.7
low density lipoprotein cholesterol measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
74.7
low density lipoprotein cholesterol measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HEN methyltransferase 1
VGNC:9038
469399
Macaque
HEN methyltransferase 1
698896
Mouse
MGI:1913965
66715
Dog
HEN methyltransferase 1
VGNC:41656
479920
Horse
HEN methyltransferase 1
VGNC:18749
100060671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HEN methyltransferase 1
Macaque
HEN methyltransferase 1
Mouse
Dog
HEN methyltransferase 1
Horse
HEN methyltransferase 1
Publication Statistics
PubMed Score 7.09
PubMed score by year
PubTator Score 2.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title