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Tbio
HEMK1
HemK methyltransferase family member 1

Protein Summary
Description
N5-glutamine methyltransferase responsible for the methylation of the GGQ triplet of the mitochondrial translation release factor MTRF1L.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232854
  • ENSP00000232854
  • ENSG00000114735
  • ENST00000434410
  • ENSP00000404843
  • ENST00000455834
  • ENSP00000404334

Symbol
  • HEMK
  • HEMK
  • MTQ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
transcription factor perturbation
0.74
protein domain
0.73
transcription factor binding site profile
0.72
phenotype
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.12   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.12   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.999932669
p_ni:  0.000063479
p_wrong:  0.000003852
Data Source:  BioPlex
MTRF1L
Tbio
Family:  Enzyme
Novelty:  0.08598685
p_int:  0.998980971
p_ni:  0.000250793
p_wrong:  0.000768236
Score:  0.847
Data Source:  BioPlex,STRINGDB
TMCO3
Tdark
Novelty:  1.16719823
p_int:  0.997834426
p_ni:  0.000452859
p_wrong:  0.001712715
Score:  0.336
Data Source:  BioPlex,STRINGDB
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
p_int:  0.996827961
p_ni:  0.00025003
p_wrong:  0.002922008
Score:  0.323
Data Source:  BioPlex,STRINGDB
N6AMT1
Tbio
Family:  Enzyme
Novelty:  0.04804276
Score:  0.869
Data Source:  STRINGDB
TRMT112
Tbio
Family:  Enzyme
Novelty:  0.05451623
Score:  0.83
Data Source:  STRINGDB
MTRF1
Tbio
Family:  Enzyme
Novelty:  0.11037387
Score:  0.78
Data Source:  STRINGDB
TRMT12
Tbio
Family:  Enzyme
Novelty:  0.12417204
Score:  0.773
Data Source:  STRINGDB
EEF1AKMT2
Tbio
Family:  Enzyme
Novelty:  0.13586312
Score:  0.689
Data Source:  STRINGDB
PPOX
Tchem
Family:  Enzyme
Novelty:  0.00652809
Score:  0.647
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
1
1.1
72.7
self reported educational attainment
1
2
2
66.6
macrophage inflammatory protein 1b measurement
1
1
1
46.5
depressive symptom measurement
4
1
4
44.2
eosinophil percentage of leukocytes
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1.1
72.7
self reported educational attainment
2
66.6
macrophage inflammatory protein 1b measurement
1
46.5
depressive symptom measurement
4
44.2
eosinophil percentage of leukocytes
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HemK methyltransferase family member 1
VGNC:11410
745237
Macaque
HemK methyltransferase family member 1
701566
Mouse
MGI:1916786
69536
Rat
RGD:1308293
300989
Dog
HemK methyltransferase family member 1
VGNC:41655
476613
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HemK methyltransferase family member 1
Macaque
HemK methyltransferase family member 1
Mouse
Rat
Dog
HemK methyltransferase family member 1
Publication Statistics
PubMed Score 29.12
PubMed score by year
PubTator Score 3.60
PubTator score by year
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Related Publications
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PMID
Year
Title