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Tbio
HELZ
Probable helicase with zinc finger domain

Protein Summary
Description
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358691
  • ENSP00000351524
  • ENSG00000198265
  • ENST00000579953
  • ENSP00000463727

Symbol
  • DRHC
  • KIAA0054
  • DHRC
  • DRHC
  • HUMORF5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
virus perturbation
0.9
transcription factor binding site profile
0.87
microRNA
0.74
transcription factor
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.9   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.9   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.999084658
p_ni:  0.000915342
Data Source:  BioPlex
RACK1
Tbio
Novelty:  0.00200617
p_int:  0.997405737
p_ni:  0.002594263
Score:  0.224
Data Source:  BioPlex,STRINGDB
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.992357707
p_ni:  0.007642293
Data Source:  BioPlex
C15orf41
Tbio
Novelty:  0.11812699
p_int:  0.984618768
p_ni:  0.015381232
Data Source:  BioPlex
CRYBG2
Tdark
Novelty:  0.7500462
p_int:  0.984611869
p_ni:  0.015388131
Data Source:  BioPlex
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.984490674
p_ni:  0.015509326
Data Source:  BioPlex
WRAP53
Tbio
Family:  Enzyme
Novelty:  0.0204638
p_int:  0.979143703
p_ni:  0.020856297
Data Source:  BioPlex
CELA3A
Tbio
Family:  Enzyme
Novelty:  0.04100319
p_int:  0.940751373
p_ni:  0.059248627
Score:  0.169
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.936857805
p_ni:  0.063142195
Data Source:  BioPlex
ESRP1
Tbio
Novelty:  0.02035464
p_int:  0.92134876
p_ni:  0.07865124
Score:  0.228
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
89
lifestyle measurement
1
1
1
46.9
lymphocyte count
2
1
2
46.5
lymphocyte percentage of leukocytes
1
1
1
46.1
neutrophil percentage of leukocytes
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
89
lifestyle measurement
1
46.9
lymphocyte count
2
46.5
lymphocyte percentage of leukocytes
1
46.1
neutrophil percentage of leukocytes
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
helicase with zinc finger
VGNC:9318
454834
Macaque
helicase with zinc finger
718729
Mouse
MGI:1925705
78455
Rat
RGD:1307049
287773
Dog
helicase with zinc finger
VGNC:41652
490907
Species
Name
OMA
EggNOG
Inparanoid
Chimp
helicase with zinc finger
Macaque
helicase with zinc finger
Mouse
Rat
Dog
helicase with zinc finger
Publication Statistics
PubMed Score 11.90
PubMed score by year
PubTator Score 7.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title