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Tbio
HECW2
E3 ubiquitin-protein ligase HECW2

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated w ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260983
  • ENSP00000260983
  • ENSG00000138411
  • ENST00000644256
  • ENSP00000494649
  • ENST00000644978
  • ENSP00000495418
  • ENST00000647236
  • ENSP00000494800

Symbol
  • KIAA1301
  • NEDL2
  • NEDL2
  • NDHSAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
histone modification site profile
0.61
microRNA
0.57
transcription factor binding site profile
0.57
interacting protein
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.22   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.22   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (299)
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.999999896
p_ni:  9.4e-8
p_wrong:  1e-8
Score:  0.313
Data Source:  BioPlex,STRINGDB
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.999999223
p_ni:  7.74e-7
p_wrong:  3e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
CUEDC1
Tbio
Novelty:  0.14401061
p_int:  0.999994398
p_ni:  0.000005602
Data Source:  BioPlex
ARRDC3
Tbio
Novelty:  0.04840692
p_int:  0.999989949
p_ni:  0.000010045
p_wrong:  6e-9
Score:  0.643
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999981161
p_ni:  0.000018838
p_wrong:  1e-9
Data Source:  BioPlex
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.999940254
p_ni:  0.000059746
Score:  0.177
Data Source:  BioPlex,STRINGDB
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.999925707
p_ni:  0.000074293
Data Source:  BioPlex
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.99949523
p_ni:  0.000504742
p_wrong:  2.7e-8
Score:  0.519
Data Source:  BioPlex,STRINGDB
SPART
Tbio
Novelty:  0.01524727
p_int:  0.971720159
p_ni:  0.028279804
p_wrong:  3.6e-8
Score:  0.221
Data Source:  BioPlex,STRINGDB
TMEM51
Tdark
Novelty:  0.54147214
p_int:  0.93172835
p_ni:  0.068227961
p_wrong:  0.000043689
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
76.2
mean corpuscular volume
1
1
1
61
eosinophil percentage of leukocytes
1
1
1
53.7
eosinophil count
2
1
2
46.5
red blood cell distribution width
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
76.2
mean corpuscular volume
1
61
eosinophil percentage of leukocytes
1
53.7
eosinophil count
2
46.5
red blood cell distribution width
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
VGNC:1959
459844
Macaque
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
697155
Mouse
MGI:2685817
329152
Rat
RGD:1593244
316395
Dog
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
VGNC:41646
100685500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Macaque
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Mouse
Rat
Dog
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Publication Statistics
PubMed Score 22.22
PubMed score by year
PubTator Score 8.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title