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Tbio
HECTD1
E3 ubiquitin-protein ligase HECTD1

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399332
  • ENSP00000382269
  • ENSG00000092148
  • ENST00000553700
  • ENSP00000450697

Symbol
  • KIAA1131
  • EULIR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
small molecule perturbation
0.9
histone modification site profile
0.86
transcription factor perturbation
0.84
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.69   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.69   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (281)
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.997826476
p_ni:  0.002173524
Score:  0.153
Data Source:  BioPlex,STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
p_int:  0.996534191
p_ni:  0.003465809
Score:  0.924
Data Source:  BioPlex,STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
p_int:  0.987775679
p_ni:  0.012224321
Score:  0.924
Data Source:  BioPlex,STRINGDB
ZNF695
Tdark
Family:  TF
Novelty:  0.37164664
p_int:  0.981019677
p_ni:  0.018980323
Score:  0.189
Data Source:  BioPlex,STRINGDB
BMP15
Tbio
Novelty:  0.00364888
p_int:  0.975807196
p_ni:  0.024192804
Score:  0.223
Data Source:  BioPlex,STRINGDB
TTLL1
Tdark
Family:  Enzyme
Novelty:  0.09244899
p_int:  0.97275709
p_ni:  0.02724291
Score:  0.181
Data Source:  BioPlex,STRINGDB
CINP
Tbio
Family:  Enzyme
Novelty:  0.07004715
p_int:  0.955540429
p_ni:  0.044459571
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
SSH2
Tbio
Family:  Enzyme
Novelty:  0.05112042
p_int:  0.944727858
p_ni:  0.055272142
Data Source:  BioPlex
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
p_int:  0.92604183
p_ni:  0.07395817
Score:  0.187
Data Source:  BioPlex,STRINGDB
CAPN6
Tbio
Novelty:  0.04489237
p_int:  0.90235269
p_ni:  0.09764731
Score:  0.214
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
1
1
24.5
low density lipoprotein cholesterol measurement
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
24.5
low density lipoprotein cholesterol measurement
1
4.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT domain E3 ubiquitin protein ligase 1
VGNC:7444
452840
Macaque
HECT domain E3 ubiquitin protein ligase 1
717177
Mouse
MGI:2384768
207304
Rat
RGD:1561653
362736
Dog
HECT domain E3 ubiquitin protein ligase 1
VGNC:41642
480284
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT domain E3 ubiquitin protein ligase 1
Macaque
HECT domain E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
HECT domain E3 ubiquitin protein ligase 1
Publication Statistics
PubMed Score 3.69
PubMed score by year
PubTator Score 5.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title