Protein Summary
Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
- ENST00000427183
- ENSP00000399139
- ENSG00000115677
- HBP
- VGL
- HBP
- VGL
- PRO2900
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
transcription factor perturbation | 1 | ||
kinase perturbation | 0.96 | ||
transcription factor binding site profile | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.48 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 302 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.48 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 302 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (142)
SERPINB2
Novelty: 0.00204345
p_int: 0.999852543
p_ni: 0.000147457
Score: 0.176
Data Source: BioPlex,STRINGDB
TENT5A
Novelty: 0.08412895
p_int: 0.998461901
p_ni: 0.001538099
Score: 0.375
Data Source: BioPlex,STRINGDB
GTF2E2
Novelty: 0.18033153
p_int: 0.997141925
p_ni: 0.002858075
Score: 0.167
Data Source: BioPlex,STRINGDB
CYP1A1
Novelty: 0.0002404
p_int: 0.995602374
p_ni: 0.004397626
Score: 0.221
Data Source: BioPlex,STRINGDB
HDHD2
Family: Enzyme
Novelty: 0.2896237
p_int: 0.989381524
p_ni: 0.010618476
Score: 0.255
Data Source: BioPlex,STRINGDB
SNRNP27
Novelty: 0.0175187
p_int: 0.984077956
p_ni: 0.015922044
Score: 0.161
Data Source: BioPlex,STRINGDB
FGB
Novelty: 0.00437751
p_int: 0.977341539
p_ni: 0.022658461
Score: 0.191
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | HDL clearance | ||||
Reactome | Plasma lipoprotein assembly, remodeling, and clearance | ||||
Reactome | Plasma lipoprotein clearance | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
HDL clearance | ||||
Plasma lipoprotein assembly, remodeling, and clearance | ||||
Plasma lipoprotein clearance | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 2 | 2 | 2 | 87.5 | |||||
C-reactive protein measurement | 2 | 2 | 2 | 85 | |||||
fibrinogen measurement | 4 | 2 | 4 | 82.6 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 79.4 | |||||
alkaline phosphatase measurement | 2 | 2 | 1 | 6.3 | 77 | ||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 2 | 87.5 | |||||
C-reactive protein measurement | 2 | 85 | |||||
fibrinogen measurement | 4 | 82.6 | |||||
apolipoprotein A 1 measurement | 2 | 79.4 | |||||
alkaline phosphatase measurement | 1 | 6.3 | 77 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | high density lipoprotein binding protein | VGNC:1958 | 743961 | |||||
Macaque | high density lipoprotein binding protein | 700945 | ||||||
Mouse | MGI:99256 | 110611 | ||||||
Rat | RGD:620962 | 64474 | ||||||
Dog | high density lipoprotein binding protein | VGNC:41631 | 477431 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | high density lipoprotein binding protein | |||||
Macaque | high density lipoprotein binding protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | high density lipoprotein binding protein | |||||
Publication Statistics
PubMed Score 106.48
PubMed score by year
PubTator Score 109.30
PubTator score by year
Related Publications
Text Mined References (46)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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