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Tbio
HDGFL3
Hepatoma-derived growth factor-related protein 3

Protein Summary
Description
Enhances DNA synthesis and may play a role in cell proliferation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299633
  • ENSP00000299633
  • ENSG00000166503

Symbol
  • HDGF2
  • HDGFRP3
  • HDGF2
  • HRP-3
  • HDGF-2
  • CGI-142
  • HDGFRP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.29   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.29   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999999947
p_ni:  2e-9
p_wrong:  5.1e-8
Data Source:  BioPlex
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
p_int:  0.984139221
p_ni:  0.015830844
p_wrong:  0.000029935
Score:  0.211
Data Source:  BioPlex,STRINGDB
BSCL2
Tbio
Novelty:  0.00483959
p_int:  0.974118161
p_ni:  0.025224273
p_wrong:  0.000657566
Data Source:  BioPlex
SENP8
Tchem
Family:  Enzyme
Novelty:  0.00774396
p_int:  0.972853774
p_ni:  0.025692431
p_wrong:  0.001453794
Score:  0.309
Data Source:  BioPlex,STRINGDB
MTERF2
Tbio
Novelty:  0.0942186
p_int:  0.953525786
p_ni:  0.045212002
p_wrong:  0.001262212
Score:  0.323
Data Source:  BioPlex,STRINGDB
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.952187632
p_ni:  0.046546544
p_wrong:  0.001265824
Data Source:  BioPlex
ZNF280A
Tdark
Novelty:  0.20436014
p_int:  0.95142305
p_ni:  0.047375505
p_wrong:  0.001201445
Score:  0.309
Data Source:  BioPlex,STRINGDB
BAZ2B
Tchem
Family:  TF; Epigenetic
Novelty:  0.00518472
p_int:  0.947286315
p_ni:  0.0027053
p_wrong:  0.050008385
Score:  0.327
Data Source:  BioPlex,STRINGDB
CDK17
Tchem
Family:  Kinase
Novelty:  0.25046297
p_int:  0.94236972
p_ni:  0.013840111
p_wrong:  0.043790169
Score:  0.215
Data Source:  BioPlex,STRINGDB
ZNF34
Tdark
Family:  TF
Novelty:  0.56369241
p_int:  0.928146043
p_ni:  0.058819936
p_wrong:  0.01303402
Score:  0.186
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
62
glomerular filtration rate
1
1
1
50.6
BMI-adjusted hip circumference
1
2
2
31.1
1
1
0
1.1
26.6
hair color
1
1
0
1.1
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
62
glomerular filtration rate
1
50.6
BMI-adjusted hip circumference
2
31.1
0
1.1
26.6
hair color
0
1.1
17.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HDGF like 3
VGNC:14858
744410
Macaque
HDGF like 3
718684
Mouse
MGI:1352760
29877
Rat
RGD:628773
252941
Chicken
hepatoma-derived growth factor, related protein 3
CGNC:49988
415463
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HDGF like 3
Macaque
HDGF like 3
Mouse
Rat
Chicken
hepatoma-derived growth factor, related protein 3
Publication Statistics
PubMed Score 9.29
PubMed score by year
PubTator Score 11.26
PubTator score by year
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Related Publications
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PMID
Year
Title