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Tbio
HDC
Histidine decarboxylase

Protein Summary
Description
Catalyzes the biosynthesis of histamine from histidine. This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267845
  • ENSP00000267845
  • ENSG00000140287
  • ENST00000543581
  • ENSP00000440252
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
0.85
disease
0.72
PubMedID
0.66
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 600.48   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 600.48   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
HNMT
Tchem
Family:  Enzyme
Novelty:  0.00100341
Score:  0.98
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.972
Data Source:  STRINGDB
HAL
Tbio
Family:  Enzyme
Novelty:  0.01504631
Score:  0.942
Data Source:  STRINGDB
CNDP2
Tbio
Family:  Enzyme
Novelty:  0.00157228
Score:  0.929
Data Source:  STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.914
Data Source:  STRINGDB
CNDP1
Tbio
Family:  Enzyme
Novelty:  0.0102642
Score:  0.911
Data Source:  STRINGDB
CARNS1
Tbio
Family:  Enzyme
Novelty:  0.09322055
Score:  0.902
Data Source:  STRINGDB
HRH1
Tclin
Family:  GPCR
Novelty:  0.00073548
Score:  0.816
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.809
Data Source:  STRINGDB
CPA3
Tchem
Family:  Enzyme
Novelty:  0.01537101
Score:  0.797
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Histidine catabolism (R-HSA-70921)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Histidine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Histidine catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
70.7
basophil count
2
1
2
61.6
FEV/FEC ratio
1
1
1
48.7
platelet count
2
1
2
48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
70.7
basophil count
2
61.6
FEV/FEC ratio
1
48.7
platelet count
2
48
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histidine decarboxylase
VGNC:1932
453425
Macaque
histidine decarboxylase
715287
Mouse
MGI:96062
15186
Rat
RGD:2790
24443
Dog
histidine decarboxylase
VGNC:41625
487551
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histidine decarboxylase
Macaque
histidine decarboxylase
Mouse
Rat
Dog
histidine decarboxylase
Publication Statistics
PubMed Score 600.48
PubMed score by year
PubTator Score 518.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title