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Tclin
HDAC9
Histone deacetylase 9

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401921
  • ENSP00000383912
  • ENSG00000048052
  • ENST00000405010
  • ENSP00000384382
  • ENST00000406451
  • ENSP00000384657
  • ENST00000417496
  • ENSP00000401669
  • ENST00000428307
  • ENSP00000395655
  • ENST00000432645
  • ENSP00000410337
  • ENST00000441542
  • ENSP00000408617
  • ENST00000456174
  • ENSP00000388568
  • ENST00000524023
  • ENSP00000430036

Symbol
  • HDAC7
  • HDAC7B
  • HDRP
  • KIAA0744
  • MITR
  • HD7
  • HD9
  • HD7b
  • HDAC
  • HDRP
  • MITR
  • HDAC7
  • HDAC7B
  • HDAC9B
  • HDAC9FL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
virus perturbation
0.99
biological process
0.96
molecular function
0.96
hub protein
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.43   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 532   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.43   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 532   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 123
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4