Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription f ...more
- ENST00000080059
- ENSP00000080059
- ENSG00000061273
- ENST00000354334
- ENSP00000351326
- ENST00000427332
- ENSP00000404394
- ENST00000552960
- ENSP00000448532
- HDAC7A
- HD7
- HD7A
- HDAC7A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.98 | ||
molecular function | 0.98 | ||
biological process | 0.9 | ||
kinase | 0.75 | ||
small molecule perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 591 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 591 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 103
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (103)
Protein-Protein Interactions (225)
TTF2
Novelty: 0.20281859
p_int: 0.99995769
p_ni: 0.00004231
Score: 0.216
Data Source: BioPlex,STRINGDB
MOCOS
Family: Enzyme
Novelty: 0.05022905
p_int: 0.999952218
p_ni: 0.000047782
Data Source: BioPlex
UGP2
Family: Enzyme
Novelty: 0.00760963
p_int: 0.998080603
p_ni: 0.001919397
Score: 0.21
Data Source: BioPlex,STRINGDB
HINT1
Novelty: 0.00815168
p_int: 0.99676909
p_ni: 0.00323091
Score: 0.485
Data Source: BioPlex,STRINGDB
DCAF10
Novelty: 2.6713128
p_int: 0.934500421
p_ni: 0.065499579
Score: 0.478
Data Source: BioPlex,STRINGDB
FLYWCH2
Novelty: 1.44186144
p_int: 0.928820512
p_ni: 0.071178634
p_wrong: 8.54e-7
Data Source: BioPlex
ZYG11B
Novelty: 0.14657862
p_int: 0.926629895
p_ni: 0.073370105
Score: 0.152
Data Source: BioPlex,STRINGDB
RHOA
Family: Enzyme
Novelty: 0.00022204
p_int: 0.921432559
p_ni: 0.057591228
p_wrong: 0.020976213
Score: 0.242
Data Source: BioPlex,STRINGDB
WDR73
Novelty: 0.10253438
p_int: 0.881544693
p_ni: 0.118455109
p_wrong: 1.99e-7
Score: 0.496
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (41)
Reactome (24)
KEGG (2)
PathwayCommons (9)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Disease | ||||
Diseases of signal transduction | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (10)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (31)
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 3 | 3 | 94.8 | |||||
platelet crit | 2 | 3 | 3 | 93.1 | |||||
mean platelet volume | 2 | 2 | 3 | 82.5 | |||||
waist-hip ratio | 1 | 2 | 2 | 81.4 | |||||
BMI-adjusted waist-hip ratio | 6 | 2 | 7 | 79.5 | |||||
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 3 | 94.8 | |||||
platelet crit | 3 | 93.1 | |||||
mean platelet volume | 3 | 82.5 | |||||
waist-hip ratio | 2 | 81.4 | |||||
BMI-adjusted waist-hip ratio | 7 | 79.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histone deacetylase 7 | VGNC:5414 | 466968 | |||||
Mouse | MGI:1891835 | 56233 | ||||||
Dog | histone deacetylase 7 | VGNC:49112 | 486589 | |||||
Horse | histone deacetylase 7 | VGNC:50596 | 100050617 | |||||
Cow | histone deacetylase 7 | VGNC:49060 | 509843 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histone deacetylase 7 | |||||
Mouse | ||||||
Dog | histone deacetylase 7 | |||||
Horse | histone deacetylase 7 | |||||
Cow | histone deacetylase 7 | |||||
Publication Statistics
PubMed Score 159.00
PubMed score by year
PubTator Score 79.32
PubTator score by year
Related Publications
Text Mined References (85)
GeneRif Annotations (52)
Items per page:
0 of 0
PMID | Year | Title |
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