Tclin HDAC7 Histone deacetylase 7

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WUI4
• B3KY08
• B4DWI0
• B4E0Q5
• Q6P1W9
• Q6W9G7
• Q7Z4K2
• Q7Z5I1
• Q96K01
• Q9BR73
• Q9H7L0
• Q9NW41
• Q9NWA9
• Q9NYK9
• Q9UFU7
• HD7

Gene Name

• HDAC7

Ensembl ID

• ENST00000080059
• ENSP00000080059
• ENSG00000061273
• ENST00000354334
• ENSP00000351326
• ENST00000427332
• ENSP00000404394
• ENST00000552960
• ENSP00000448532

Symbol

• HDAC7A
• HD7
• HD7A
• HDAC7A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
molecular function	0.98
biological process	0.9
kinase	0.75
small molecule perturbation	0.74

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class Iia / Histone Deacetylase 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.66   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 591   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.66   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 591   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 136

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4