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Tclin
HDAC7
Histone deacetylase 7

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000080059
  • ENSP00000080059
  • ENSG00000061273
  • ENST00000354334
  • ENSP00000351326
  • ENST00000427332
  • ENSP00000404394
  • ENST00000552960
  • ENSP00000448532

Symbol
  • HDAC7A
  • HD7
  • HD7A
  • HDAC7A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
molecular function
0.98
biological process
0.9
kinase
0.75
small molecule perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.66   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 591   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.66   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 591   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 136
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4