Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggres ...more
- ENST00000334136
- ENSP00000334061
- ENSG00000094631
- ENST00000376619
- ENSP00000365804
- ENST00000426196
- ENSP00000402189
- ENST00000643374
- ENSP00000496046
- ENST00000644068
- ENSP00000496013
- KIAA0901
- HD6
- JM21
- CPBHM
- PPP1R90
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
histone modification site profile | 0.9 | ||
interacting protein | 0.89 | ||
hub protein | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1023.43 (req: < 5)
Gene RIFs: 214 (req: <= 3)
Antibodies: 978 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1023.43 (req: >= 5)
Gene RIFs: 214 (req: > 3)
Antibodies: 978 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 68
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2329
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (2329)
Protein-Protein Interactions (356)
TUBA3C
Novelty: 0.0187396
p_int: 0.99999557
p_ni: 0.00000443
Score: 0.174
Data Source: BioPlex,STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
p_int: 0.999946969
p_ni: 0.000052888
p_wrong: 1.43e-7
Score: 0.21
Data Source: BioPlex,STRINGDB
LPIN3
Family: Enzyme
Novelty: 0.01641336
p_int: 0.999903133
p_ni: 0.00009685
p_wrong: 1.7e-8
Score: 0.201
Data Source: BioPlex,STRINGDB
UBL7
Novelty: 0.20935024
p_int: 0.999675342
p_ni: 0.000324148
p_wrong: 5.1e-7
Score: 0.613
Data Source: BioPlex,STRINGDB
TIMM50
Family: Enzyme
Novelty: 0.0238053
p_int: 0.999500946
p_ni: 0.000499054
p_wrong: 1e-9
Score: 0.199
Data Source: BioPlex,STRINGDB
CHEK1
Family: Kinase
Novelty: 0.00066843
p_int: 0.999452122
p_ni: 0.000547878
Score: 0.256
Data Source: BioPlex,STRINGDB
KCNAB3
Family: IC
Novelty: 0.10128237
p_int: 0.999265822
p_ni: 0.000734176
p_wrong: 2e-9
Score: 0.267
Data Source: BioPlex,STRINGDB
NYAP2
Family: Enzyme
Novelty: 1.08965558
p_int: 0.998392308
p_ni: 0.001606304
p_wrong: 0.000001388
Data Source: BioPlex
MCM7
Novelty: 0.0017984
p_int: 0.998253088
p_ni: 0.001745688
p_wrong: 0.000001224
Score: 0.238
Data Source: BioPlex,STRINGDB
TULP2
Family: TF
Novelty: 0.20144336
p_int: 0.998182874
p_ni: 0.001793295
p_wrong: 0.000023831
Score: 0.159
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (39)
Reactome (24)
KEGG (2)
PathwayCommons (4)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Cilium Assembly | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Cilium Assembly | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Viral Interactions (0)
Gene Ontology Terms (85)
Functions (19)
Components (17)
Processes (49)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 1 | 2 | 2 | 90 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 82.8 | |||||
platelet count | 1 | 1 | 1 | 57.8 | |||||
mean platelet volume | 1 | 1 | 1 | 15.5 | |||||
1 | 1 | 0 | 1.1 | 2.4 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 2 | 90 | |||||
eosinophil percentage of leukocytes | 1 | 82.8 | |||||
platelet count | 1 | 57.8 | |||||
mean platelet volume | 1 | 15.5 | |||||
0 | 1.1 | 2.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | histone deacetylase 6 | 711363 | ||||||
Mouse | MGI:1333752 | 15185 | ||||||
Rat | RGD:619981 | 84581 | ||||||
Rat | RGD:11442569 | 108348065 | ||||||
Dog | histone deacetylase 6 | VGNC:50630 | 480907 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | histone deacetylase 6 | |||||
Mouse | ||||||
Rat | ||||||
Rat | ||||||
Dog | histone deacetylase 6 | |||||
Publication Statistics
PubMed Score 1023.43
PubMed score by year
PubTator Score 517.11
PubTator score by year
Related Publications
Text Mined References (262)
GeneRif Annotations (214)
Items per page:
0 of 0
PMID | Year | Title |
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