Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetyla ...more
- ENST00000225983
- ENSP00000225983
- ENSG00000108840
- ENST00000336057
- ENSP00000337290
- ENST00000586802
- ENSP00000468004
- KIAA0600
- HD5
- NY-CO-9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
kinase | 1 | ||
disease perturbation | 0.99 | ||
hub protein | 0.99 | ||
molecular function | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 211.17 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 681 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 211.17 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 681 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 91
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (91)
Protein-Protein Interactions (268)
LTBR
Novelty: 0.003823
p_int: 0.999999959
p_wrong: 4.1e-8
Score: 0.248
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (60)
Reactome (19)
KEGG (4)
PathwayCommons (4)
WikiPathways (33)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Disease | ||||
Diseases of signal transduction | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (11)
Components (7)
Processes (22)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 3 | 6 | 96.8 | |||||
HbA1c measurement | 2 | 2 | 2 | 85.3 | |||||
femoral neck bone mineral density | 1 | 1 | 1 | 76.3 | |||||
bone density | 2 | 3 | 4 | 64.9 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 61.4 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 6 | 96.8 | |||||
HbA1c measurement | 2 | 85.3 | |||||
femoral neck bone mineral density | 1 | 76.3 | |||||
bone density | 4 | 64.9 | |||||
mean reticulocyte volume | 1 | 61.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histone deacetylase 5 | VGNC:9316 | 454721 | |||||
Macaque | histone deacetylase 5 | 711456 | ||||||
Mouse | MGI:1333784 | 15184 | ||||||
Rat | RGD:619980 | 84580 | ||||||
Dog | histone deacetylase 5 | VGNC:49093 | 490941 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histone deacetylase 5 | |||||
Macaque | histone deacetylase 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone deacetylase 5 | |||||
Publication Statistics
PubMed Score 211.17
PubMed score by year
PubTator Score 137.60
PubTator score by year
Related Publications
GeneRif Annotations (60)
Items per page:
0 of 0
PMID | Text |
|---|