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Tclin
HDAC2
Histone deacetylase 2

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368632
  • ENSP00000357621
  • ENSG00000196591
  • ENST00000519065
  • ENSP00000430432
  • ENST00000519108
  • ENSP00000430008

Symbol
  • HD2
  • RPD3
  • YAF1
  • KDAC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
co-expressed gene
1
hub protein
1
interacting protein
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1087.69   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 892   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1087.69   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 892   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1182
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6