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Tclin
HDAC11
Histone deacetylase 11

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295757
  • ENSP00000295757
  • ENSG00000163517
  • ENST00000522202
  • ENSP00000429794

Symbol
  • HD11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
cellular component
0.74
molecular function
0.7
small molecule perturbation
0.69
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.62   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.62   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 173
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (173)
fimepinostat
Rendered image for fimepinostat
trichostatin
Rendered image for trichostatin
Belinosta
Rendered image for Belinosta
CHEMBL1830424
Rendered image for CHEMBL1830424
dacinostat
Rendered image for dacinostat
KA1010
Rendered image for KA1010
pracinostat
Rendered image for pracinostat
quisinostat
Rendered image for quisinostat
scriptaid
Rendered image for scriptaid
Protein-Protein Interactions (166)
PAXBP1
Tbio
Novelty:  0.13631396
p_int:  0.999998242
p_ni:  0.000001758
Score:  0.228
Data Source:  BioPlex,STRINGDB
ATG2B
Tbio
Novelty:  0.04963717
p_int:  0.999995964
p_ni:  0.000004036
Score:  0.189
Data Source:  BioPlex,STRINGDB
GCFC2
Tbio
Novelty:  0.04245608
p_int:  0.999992217
p_ni:  0.000007783
Data Source:  BioPlex
RSRC1
Tbio
Novelty:  0.12148079
p_int:  0.999985544
p_ni:  0.000014261
p_wrong:  1.95e-7
Score:  0.664
Data Source:  BioPlex,STRINGDB
TFIP11
Tbio
Novelty:  0.01546496
p_int:  0.999969242
p_ni:  0.000030758
Score:  0.188
Data Source:  BioPlex,STRINGDB
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.994710771
p_ni:  0.005289229
Data Source:  BioPlex
WDR45
Tbio
Novelty:  0.0148072
p_int:  0.994487228
p_ni:  0.005512767
p_wrong:  5e-9
Score:  0.552
Data Source:  BioPlex,STRINGDB
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
p_int:  0.961595041
p_ni:  0.038404959
Data Source:  BioPlex
C16orf62
Tdark
Novelty:  0.33867321
p_int:  0.960653111
p_ni:  0.039346889
Score:  0.161
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.958523798
p_ni:  0.041476202
Score:  0.16
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (41)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Diseases of signal transduction
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
6
74
red blood cell distribution width
1
1
1
38.8
body mass index
1
1
1
14.2
corneal topography
1
1
1
11.6
body height
1
1
1
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
74
red blood cell distribution width
1
38.8
body mass index
1
14.2
corneal topography
1
11.6
body height
1
6.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 11
VGNC:11409
460190
Macaque
histone deacetylase 11
693537
Mouse
MGI:2385252
232232
Rat
RGD:1311706
297453
Dog
histone deacetylase 11
VGNC:50627
484633
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 11
Macaque
histone deacetylase 11
Mouse
Rat
Dog
histone deacetylase 11
Publication Statistics
PubMed Score 88.62
PubMed score by year
PubTator Score 61.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title