Protein Summary
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
- ENST00000293330
- ENSP00000293330
- ENSG00000161610
- OX
- PPORX
- PPOX
- OX
- PPOX
- NRCLP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue | 0.87 | ||
biological term | 0.81 | ||
cellular component | 0.76 | ||
biological process | 0.74 | ||
cell type or tissue | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3277.11 (req: < 5)
Gene RIFs: 101 (req: <= 3)
Antibodies: 310 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3277.11 (req: >= 5)
Gene RIFs: 101 (req: > 3)
Antibodies: 310 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (266)
Nearest Tclin Targets
Pathways (9)
Reactome (8)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (3)
Components (7)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 77.8 | |||||
3 | 2 | 3 | 65.7 | ||||||
mean reticulocyte volume | 1 | 1 | 1 | 65.6 | |||||
Thyroid preparation use measurement | 1 | 1 | 1 | 61.4 | |||||
waist-hip ratio | 1 | 1 | 1 | 57.8 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 77.8 | |||||
3 | 65.7 | ||||||
mean reticulocyte volume | 1 | 65.6 | |||||
Thyroid preparation use measurement | 1 | 61.4 | |||||
waist-hip ratio | 1 | 57.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hypocretin neuropeptide precursor | VGNC:12260 | 742546 | |||||
Macaque | hypocretin neuropeptide precursor | 709564 | ||||||
Mouse | MGI:1202306 | 15171 | ||||||
Rat | RGD:2786 | 25723 | ||||||
Dog | hypocretin neuropeptide precursor | VGNC:41622 | 607641 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hypocretin neuropeptide precursor | |||||
Macaque | hypocretin neuropeptide precursor | |||||
Mouse | ||||||
Rat | ||||||
Dog | hypocretin neuropeptide precursor | |||||
Publication Statistics
PubMed Score 3277.11
PubMed score by year
PubTator Score 810.46
PubTator score by year
Related Publications
Text Mined References (122)
GeneRif Annotations (101)
Items per page:
0 of 0
PMID | Year | Title |
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