Tbio HCRT Orexin

Protein Summary

Description

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• O43612

Gene Name

• HCRT

Ensembl ID

• ENST00000293330
• ENSP00000293330
• ENSG00000161610

Symbol

• OX
• PPORX
• PPOX
• OX
• PPOX
• NRCLP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.87
biological term	0.81
cellular component	0.76
biological process	0.74
cell type or tissue	0.66

Protein Classes

DTO Classes

Orexin Receptor Type 2 / Orexin Receptor Type 1 / Orexin B / Orexin A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3628.69   (req: < 5)

Gene RIFs: 125   (req: <= 3)

Antibodies: 310   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3628.69   (req: >= 5)

Gene RIFs: 125   (req: > 3)

Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0