Tclin HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Protein Summary

Description

Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q9Y3Q4
• Q9UMQ7

Gene Name

• HCN4

Ensembl ID

• ENST00000261917
• ENSP00000261917
• ENSG00000138622

Symbol

• SSS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.97
biological process	0.68
microRNA	0.66
cell type or tissue	0.57

Protein Classes

DTO Classes

Protein / Ion Channel / Cyclic Nucleotide-gated Cation Channel Family / Potassium/sodium Hyperpolarization-activated Cyclic Nucleotide-gated Channel 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 581.16   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 581.16   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3